A Clinical Trial to Evaluate the Safety and Efficacy of DR-2041(Synthetic Conjugated Estrogens, A) for Treatment of Vulvovaginal Atrophy

NCT ID: NCT00361569

Last Updated: 2015-04-20

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

622 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-08-31

Study Completion Date

2007-09-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This is a four-arm, randomized, double-blind, parallel group, placebo-controlled study to compare the effects of two doses of DR-2041(Synthetic Conjugated Estrogens, A) Vaginal Cream on vulvovaginal atrophy in postmenopausal women with or without a hysterectomy and/or oophorectomy.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The study will include a screening period up to 4 weeks and a 12- week treatment period. The overall study duration for participants will be approximately 16 weeks. Study participants will undergo physical and gynecological exams, and blood tests for clinical laboratory assessments. All patients with a uterus will undergo transvaginal ultrasound.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Menopause

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

1

Group Type EXPERIMENTAL

DR-2041a

Intervention Type DRUG

1 gram administered vaginally daily for the 1st 7 days then twice a week thereafter

2

Group Type EXPERIMENTAL

DR-2041b

Intervention Type DRUG

2 grams administered vaginally daily for the 1st 7 days then twice a week thereafter

3

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type OTHER

1 gram administered vaginally daily for the 1st 7 days then twice a week thereafter

4

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type OTHER

2 grams administered vaginally daily for the 1st 7 days then twice a week thereafter

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

DR-2041a

1 gram administered vaginally daily for the 1st 7 days then twice a week thereafter

Intervention Type DRUG

DR-2041b

2 grams administered vaginally daily for the 1st 7 days then twice a week thereafter

Intervention Type DRUG

Placebo

1 gram administered vaginally daily for the 1st 7 days then twice a week thereafter

Intervention Type OTHER

Placebo

2 grams administered vaginally daily for the 1st 7 days then twice a week thereafter

Intervention Type OTHER

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Synthetic conjugated estrogens, A Synthetic conjugated estrogens, A

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Naturally or surgically menopausal
* Moderate or severe symptoms of vaginal atrophy (ie, dryness, itching, pain, uncomfortable intercourse)

Exclusion Criteria

* Known sensitivity or contraindication to estrogens or progestins
* History or current diagnosis endometrial hyperplasia
* Recent history of vaginal bleeding of unknown cause
* Recent history or diagnosis of endometriosis
* Any contraindication to estrogen therapy
Minimum Eligible Age

30 Years

Maximum Eligible Age

80 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Duramed Research

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Duramed Research, Inc.

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Duramed Protocol Chair

Role: STUDY_CHAIR

Duramed Research, Inc.

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Duramed Investigational Site

Huntsville, Alabama, United States

Site Status

Duramed Investigational Site

Mobile, Alabama, United States

Site Status

Duramed Investigational Site

Montgomery, Alabama, United States

Site Status

Duramed Investigational Site

Phoenix, Arizona, United States

Site Status

Duramed Investigational Site

Phoenix, Arizona, United States

Site Status

Duramed Investigational Site

Phoenix, Arizona, United States

Site Status

Duramed Investigational Site

Tucson, Arizona, United States

Site Status

Duramed Investigational Site

Carmichael, California, United States

Site Status

Duramed Investigational Site

Fresno, California, United States

Site Status

Duramed Investigational Site

San Diego, California, United States

Site Status

Duramed Investigational Site

San Diego, California, United States

Site Status

Duramed Investigational Site

San Diego, California, United States

Site Status

Duramed Investigational Site

San Ramon, California, United States

Site Status

Duramed Investigational Site

Colorado Springs, Colorado, United States

Site Status

Duramed Investigational Site

Pueblo, Colorado, United States

Site Status

Duramed Investigational Site

New London, Connecticut, United States

Site Status

Duramed Investigational Site

Clearwater, Florida, United States

Site Status

Duramed Investigational Site

Clearwater, Florida, United States

Site Status

Duramed Investigational Site

Gainesville, Florida, United States

Site Status

Duramed Investigational Site

Jacksonville, Florida, United States

Site Status

Duramed Investigational Site

Leesburg, Florida, United States

Site Status

Duramed Investigational Site

Miami, Florida, United States

Site Status

Duramed Investigational Site

Pinellas Park, Florida, United States

Site Status

Duramed Investigational Site

Stuart, Florida, United States

Site Status

Duramed Investigational Site

Tampa, Florida, United States

Site Status

Duramed Investigational Site

Tampa, Florida, United States

Site Status

Duramed Investigational Site

Venice, Florida, United States

Site Status

Duramed Investigational Site

West Palm Beach, Florida, United States

Site Status

Duramed Investigational Site

West Palm Beach, Florida, United States

Site Status

Duramed Investigational Site

Weston, Florida, United States

Site Status

Duramed Investigational Site

Alpharetta, Georgia, United States

Site Status

Duramed Investigational Site

Atlanta, Georgia, United States

Site Status

Duramed Investigational Site

Augusta, Georgia, United States

Site Status

Duramed Investigational Site

Decatur, Georgia, United States

Site Status

Duramed Investigational Site

Douglasville, Georgia, United States

Site Status

Duramed Investigational Site

Sandy Springs, Georgia, United States

Site Status

Duramed Investigational Site

Chicago, Illinois, United States

Site Status

Duramed Investigational Site

Chicago, Illinois, United States

Site Status

Duramed Investigational Site

Evansville, Indiana, United States

Site Status

Duramed Investigational Site

Overland Park, Kansas, United States

Site Status

Duramed Investigational Site

Lexington, Kentucky, United States

Site Status

Duramed Investigational Site

Louisville, Kentucky, United States

Site Status

Duramed Investigational Site

Madisonville, Kentucky, United States

Site Status

Duramed Investigational Site

Shreveport, Louisiana, United States

Site Status

Duramed Investigational Site

Baltimore, Maryland, United States

Site Status

Duramed Investigational Site

Livonia, Michigan, United States

Site Status

Duramed Investigational Site

Lincoln, Nebraska, United States

Site Status

Duramed Investigational Site

Las Vegas, Nevada, United States

Site Status

Duramed Investigational Site

Lebanon, New Hampshire, United States

Site Status

Duramed Investigational Site

Lawrenceville, New Jersey, United States

Site Status

Duramed Investigational Site

Moorestown, New Jersey, United States

Site Status

Duramed Investigational Site

New Brunswick, New Jersey, United States

Site Status

Duramed Investigational Site

Albuquerque, New Mexico, United States

Site Status

Duramed Investigational Site

Johnson City, New York, United States

Site Status

Duramed Investigational Site

Williamsville, New York, United States

Site Status

Duramed Investigational Site

Raleigh, North Carolina, United States

Site Status

Duramed Investigational Site

Winston-Salem, North Carolina, United States

Site Status

Duramed Investigational Site

Jamestown, North Dakota, United States

Site Status

Duramed Investigational Site

Minot, North Dakota, United States

Site Status

Duramed Investigational Site

Cincinnati, Ohio, United States

Site Status

Duramed Investigational Site

Cleveland, Ohio, United States

Site Status

Duramed Investigational Site

Columbus, Ohio, United States

Site Status

Duramed Investigational Site

Columbus, Ohio, United States

Site Status

Duramed Investigational Site

Columbus, Ohio, United States

Site Status

Duramed Investigational Site

Mayfield Heights, Ohio, United States

Site Status

Duramed Investigational Site

Medford, Oregon, United States

Site Status

Duramed Investigational Site

Portland, Oregon, United States

Site Status

Duramed Investigational Site

Portland, Oregon, United States

Site Status

Duramed Investigational Site

Allentown, Pennsylvania, United States

Site Status

Duramed Investigational Site

King of Prussia, Pennsylvania, United States

Site Status

Duramed Investigational Site

Media, Pennsylvania, United States

Site Status

Duramed Investigational Site

Philadelphia, Pennsylvania, United States

Site Status

Duramed Investigational Site

Philadelphia, Pennsylvania, United States

Site Status

Duramed Investigational Site

Pittsburgh, Pennsylvania, United States

Site Status

Duramed Investigational Site

Rosemont, Pennsylvania, United States

Site Status

Duramed Investigational Site

Strafford, Pennsylvania, United States

Site Status

Duramed Investigational Site

Warwick, Rhode Island, United States

Site Status

Duramed Investigational Site

Charleston, South Carolina, United States

Site Status

Duramed Investigational Site

Charleston, South Carolina, United States

Site Status

Duramed Investigational Site

Columbia, South Carolina, United States

Site Status

Duramed Investigational Site

Watertown, South Dakota, United States

Site Status

Duramed Investigational Site

Memphis, Tennessee, United States

Site Status

Duramed Investigational Site

Nashville, Tennessee, United States

Site Status

Duramed Investigational Site

Austin, Texas, United States

Site Status

Duramed Investigational Site

Austin, Texas, United States

Site Status

Duramed Investigational Site

Corpus Christi, Texas, United States

Site Status

Duramed Investigational Site

Dallas, Texas, United States

Site Status

Duramed Investigational Site

Houston, Texas, United States

Site Status

Duramed Investigational Site

Houston, Texas, United States

Site Status

Duramed Investigational Site

Houston, Texas, United States

Site Status

Duramed Investigational Site

Houston, Texas, United States

Site Status

Duramed Investigational Site

San Antonio, Texas, United States

Site Status

Duramed Investigational Site

Waco, Texas, United States

Site Status

Duramed Investigational Site

Williston, Vermont, United States

Site Status

Duramed Investigational Site

Newport News, Virginia, United States

Site Status

Duramed Investigational Site

Spokane, Washington, United States

Site Status

Duramed Investigational Site

Tacoma, Washington, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

References

Explore related publications, articles, or registry entries linked to this study.

Freedman M, Kaunitz AM, Reape KZ, Hait H, Shu H. Twice-weekly synthetic conjugated estrogens vaginal cream for the treatment of vaginal atrophy. Menopause. 2009 Jul-Aug;16(4):735-41. doi: 10.1097/gme.0b013e318199e734.

Reference Type RESULT
PMID: 19252451 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

DR-CEN-302

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.