Biologic Effects of Dehydroepiandrosterone (DHEA) in Humans
NCT ID: NCT00099697
Last Updated: 2009-12-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
56 participants
INTERVENTIONAL
2001-06-30
2004-02-29
Brief Summary
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Detailed Description
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Participants were randomly assigned to receive 50 mg per day of DHEA or a placebo at bedtime for 6 months. Participants underwent magnetic resonance imaging (MRI) and oral glucose tolerance tests at the beginning and conclusion of the study. Other tests included measurements of hormones and lipids.
Conditions
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Keywords
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Study Design
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RANDOMIZED
PREVENTION
DOUBLE
Interventions
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DHEA
Eligibility Criteria
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Inclusion Criteria
* Physically healthy
* Non-smoker
* On stable medications for at least 6 months
* Stable body weight for the past year
Exclusion Criteria
* Hormone therapy
* Abnormal PSA (prostate specific antigen) in men
65 Years
78 Years
ALL
Yes
Sponsors
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National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
National Center for Research Resources (NCRR)
NIH
National Institute on Aging (NIA)
NIH
Principal Investigators
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John O. Holloszy, MD
Role: PRINCIPAL_INVESTIGATOR
Washington University School of Medicine
Dennis T. Villareal, MD
Role: PRINCIPAL_INVESTIGATOR
Washington University School of Medicine
Locations
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Washington University School of Medicine
St Louis, Missouri, United States
Countries
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References
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Hansen PA, Han DH, Nolte LA, Chen M, Holloszy JO. DHEA protects against visceral obesity and muscle insulin resistance in rats fed a high-fat diet. Am J Physiol. 1997 Nov;273(5):R1704-8. doi: 10.1152/ajpregu.1997.273.5.R1704.
Han DH, Hansen PA, Chen MM, Holloszy JO. DHEA treatment reduces fat accumulation and protects against insulin resistance in male rats. J Gerontol A Biol Sci Med Sci. 1998 Jan;53(1):B19-24. doi: 10.1093/gerona/53a.1.b19.
Villareal DT, Holloszy JO, Kohrt WM. Effects of DHEA replacement on bone mineral density and body composition in elderly women and men. Clin Endocrinol (Oxf). 2000 Nov;53(5):561-8. doi: 10.1046/j.1365-2265.2000.01131.x.
Villareal DT, Holloszy JO. Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial. JAMA. 2004 Nov 10;292(18):2243-8. doi: 10.1001/jama.292.18.2243.
Other Identifiers
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AG0013
Identifier Type: -
Identifier Source: org_study_id