Clinical-genetic Investigations in Children With Early Infantile Epilepsies
NCT ID: NCT01357707
Last Updated: 2018-02-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
75 participants
OBSERVATIONAL
2010-07-31
2017-12-31
Brief Summary
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The investigators hypothesize that mutations in genes coding for ion channels or genes that modify the action of ion channels might be causative.
For that the investigators will perform a sequence analysis of the coding exons of a large set of genes in all recruited patients and verify found mutations in their parents.
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Detailed Description
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Conditions
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Study Design
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FAMILY_BASED
PROSPECTIVE
Study Groups
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West Syndrome (idiopathic)
Patients with idiopathic infantile seizures
DNA preparation
Taking blood or saliva from the patient to prepare DNA therefrom
Interventions
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DNA preparation
Taking blood or saliva from the patient to prepare DNA therefrom
Eligibility Criteria
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Inclusion Criteria
* Infantile seizures in the first year of life
* Freedom of seizures at the age of 5 years
Exclusion Criteria
* metabolic disorder
* intracranial hemorrhage
* lissencephaly
5 Years
10 Years
ALL
No
Sponsors
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Mainz University
OTHER
University of Ulm
OTHER
Ludwig-Maximilians - University of Munich
OTHER
University of Kiel
OTHER
Markus Schuelke, M.D.
OTHER
Responsible Party
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Markus Schuelke, M.D.
Prinicpal investigator
Locations
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Charité Universitätsmedizin
Berlin, , Germany
Countries
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Other Identifiers
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SFB 665 TP C4
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
EA1_215_08
Identifier Type: -
Identifier Source: org_study_id
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