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Genetic Basis of Idiopathic Focal Epilepsies With Cognitif Deficits

NCT ID: NCT00851331

Last Updated: 2009-02-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Brief Summary

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Epilepsy is a frequent neurological disease in childhood, characterized by recurrent seizures and sometimes with major effects on social, behavioral and cognitive development. Childhood focal epilepsies particularly are age-related diseases mainly occurring during developmental critical period. A complex interplay between brain development and maturation processes and susceptibility genes may contribute to the development of various childhood epileptic syndromes associated with language and cognitive deficits. Indeed, the Landau-Kleffner syndrome (LKS), the continuous spike-and-waves during sleep syndrome (CSWS), and the benign childhood epilepsy with centrotemporal spikes (BCECTS) or benign rolandic epilepsy, are different syndromes that are considered as part of a single continuous spectrum of disorders. While genetic component in those three syndromes remains elusive, novel and high throughput genome analyzes could bring interesting insights into the possible genetic defects and pathophysiological mechanisms underlying and linking the various disorders associating epilepsy with speech and cognitive impairments.

Detailed Description

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Conditions

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Epilepsy

Keywords

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Benign childhood epilepsy

Interventions

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genome analyzes (genetic defects and pathophysiological mechanisms )

Intervention Type GENETIC

Eligibility Criteria

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Inclusion Criteria

* iodiopathic focal epilepsy with cognitif deficit

Exclusion Criteria

* medical history of status epilepticus
Minimum Eligible Age

4 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Strasbourg, France

OTHER

Sponsor Role lead

Responsible Party

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Direction de la Recherche Clinique et de l'Innovation - Hôpitaux Universitaires de Strasbourg

Principal Investigators

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Edouard HIRSCH, MD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Strasbourg, France

Locations

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Hôpital Femme Mère Enfant - Hospices Civils de Lyon, Service Epilepsie, Sommeil et Exploration fonctionnelle neurologique pédiatrique

Bron, 69500, France

Site Status

American Memorial Hospital, CHU de Reims, Unité de Neurologie Pédiatrique - Service Pédiatrie A

Reims, , France

Site Status

Clinique neurologique, Hôpitaux Universitaires de Strasbourg

Strasbourg, , France

Site Status

Hôpital de Hautepierre, Service de pédiatrie 1

Strasbourg, , France

Site Status

Countries

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France

Central Contacts

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Gabrielle Rudolf, PhD, HDR

Role: CONTACT

Phone: (33) 3.88.11.66.62

Email: [email protected]

Other Identifiers

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3391

Identifier Type: -

Identifier Source: org_study_id