The Study of Serum Melatonin Rhythm Levels in Patients With Major Depressive Disorder

NCT ID: NCT01357083

Last Updated: 2011-05-20

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 92 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2010-08-31
• Study Completion Date: 2010-10-31

Brief Summary

One of the main points in the biological trends is, the circadian rhythm and disturbance in this cycle, which cause mood disorders and irregularity in this bio clock, to get depression. The pineal gland with the precise regulation of circadian rhythm of melatonin regulates the brain haemostasis. The abnormal function of this gland gives rise to psychiatric disorders.

In the period of youth and early of middle-age cause biochemical changes and disturbance in biorhythm including melatonin secretion.

This process can change the peak of melatonin phase. In addition, a decrease in the level of serum melatonin, can change the function of immune system of depressed patients. This function facilitates the process of cancerous cell formation and tumor growth.

With respect to the conflicting results and that the positive and negative roles of melatonin in the creation of depression is unknown, the aim of this study was to compare the morning and nocturnal serum melatonin rhythm levels in the patients with Major Depressive Disorder. The second purpose was to measure the morning and nocturnal serum melatonin levels in the depressed and healthy men and women.

Conditions

Major Depressive Disorder

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: RETROSPECTIVE

Study Groups

Major Depression Disorder

This study is analytical cross-sectional and randomized. Two groups of depressed patients and healthy subjects were selected.The individual were submitted to a medical examination, and responded to the Beck depression inventory (BDII-II). Those, who got a score above 20, were included in the depressed group. Among this group, 50 patients were chosen randomly. those who obtained a depressive score below 9, 50 of them were chosen and they were included in the healthy group. The control group was chosen to match to the depressed patients for education, social occasion, occupational and economical situation. All of the subjects were interviewed psychiatrically, and the depression disorder was confirmed on the basis of the DSM criteria. eight out of 50 depressed patients were excluded from the study due to suffering from other psychiatric disorders .

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

1. age: 22-48 years old

2. gender: male, female

3. who got a depressive score above 20, were included in the depressed group

4. those who obtained a depressive score below 9, were chosen and they were included in the healthy control group.

5. the healthy control group to match to the depressed patients for education, social occasion, occupational and economical situation.

6. the depression disorder was confirmed on the basis of the DSM criteria

Exclusion Criteria

1. present or past psychiatric

2. physical diagnoses

3. drug consumption

4. use of narcotic substances

5. physical and psychosomatic disorders

6. the stressor

7. malfunction of thyroid gland

8. shift working

• Minimum Eligible Age: 22 Years
• Maximum Eligible Age: 48 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Science & Research Islamic Azad University Branch Khozestan

OTHER

Sponsor Role: lead

Responsible Party

Science & Research Islamic Azad University Branch Khozestan

Principal Investigators

Shahnaz Khaleghipour, PhD

Role: PRINCIPAL_INVESTIGATOR

Science and Research Branch Islamic Azad University Khozestan

Locations

Shahnaz Khaleghipour

Isfahan, Isfahan, Iran

Countries

Iran

References

Khaleghipour S, Masjedi M, Ahade H, Enayate M, Pasha G, Nadery F, Ahmadzade G. Morning and nocturnal serum melatonin rhythm levels in patients with major depressive disorder: an analytical cross-sectional study. Sao Paulo Med J. 2012;130(3):167-72. doi: 10.1590/s1516-31802012000300006.

Reference Type: DERIVED

PMID: 22790549 (View on PubMed)

Other Identifiers

CCT-NAPN-21087

Identifier Type: -

Identifier Source: secondary_id

9460

Identifier Type: -

Identifier Source: org_study_id