Long-term Benefit of Aortic Stent-graft in Patients With Distal Aortic Dissection

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

TERMINATED

Clinical Phase

PHASE4

Total Enrollment

7 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-01-31

Study Completion Date

2014-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Background: Aortic stent-graft is useful to occlude intimal tear and prevent further dilatation of the false lumen in patients with aortic dissection. The long-term benefit of aortic stent-graft in patients with uncomplicated distal aortic dissection has not been well demonstrated, especially in patients at high risk of aneurysmal change and death.

Purpose: The purpose of the study is to evaluate long-term clinical benefit of stent-graft insertion performed just after the acute phase into the descending thoracic aorta in patients with distal aortic dissection and at high risk of aneurysmal change of the dissected aorta.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Endovascular Aortic Repair for Aortic Dissection

NCT01505309

Aorta Dissection Aorta Aneurysm

UNKNOWN NA

Study of Blood Clotting After Transcatheter Atrial Septal Defect Closure

NCT01086046

Thrombosis

UNKNOWN NA

Early Surgery Versus Conventional Treatment in Very Severe Aortic Stenosis

NCT01161732

Aortic Stenosis

COMPLETED NA

Study of Platelet Activation by Severe Aortic Stenosis and Its Correction by Transcatheter Aortic Valve Implantation

NCT02504632

Aortic Stenosis

COMPLETED NA

Triple-branch Stent Graft Placement and Total-arch Replacement for the Treatment of Acute DeBakey I Aortic Dissection

NCT02622750

Acute Aortic Dissection

UNKNOWN EARLY_PHASE1

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Aortic Dissection Aortic Aneurysm Stent-graft

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Early intervention

Early intervention: stent-graft just after acute phase

Group Type ACTIVE_COMPARATOR

Aortic stent-graft

Intervention Type PROCEDURE

Early intervention with aortic stent-graft

Conservative

Conservative: medial follow-up without early intervention

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Aortic stent-graft

Early intervention with aortic stent-graft

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Uncomplicated distal aortic dissection
* Initial false lumen diameter \>= 22 mm

Exclusion Criteria

* Old age (\> 75 years old)
* Other comorbidity or malignancy with life expectancy \< 5 years
* Complicated dissection requiring aortic surgery or intervention
* Sudden death in acute phase
* Marfan syndrome

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No