LLLT Combined With CDT in Breast Cancer-Related Lymphedema

NCT ID: NCT01351376

Last Updated: 2019-09-19

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

21 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-05-31

Study Completion Date

2017-07-31

Brief Summary

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This study aims to explore the effects of Low Level Laser Therapy (LLLT) on breast cancer-related lymphedema when utilized in conjunction with Complex Decongestive Therapy (CDT) when compared to CDT treatment alone. The investigators hypothesize that the addition of LLLT to CDT will result in statistically significant improvements and greater long-term benefits as measured by changes in arm volume and quality of life when compared to the benefits of CDT alone for the treatment of breast cancer-related lymphedema.

Detailed Description

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Conditions

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Breast Cancer Lymphedema

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Placebo

CDT + inactive LLL

Group Type PLACEBO_COMPARATOR

Low Level Laser Therapy

Intervention Type DEVICE

Placebo LLL combined with CDT

LLL combined with CDT

CDT + active LLL

Group Type ACTIVE_COMPARATOR

Low Level Laser

Intervention Type DEVICE

Active LLL combined with CDT

Interventions

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Low Level Laser Therapy

Placebo LLL combined with CDT

Intervention Type DEVICE

Low Level Laser

Active LLL combined with CDT

Intervention Type DEVICE

Other Intervention Names

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Low Level Laser Complex Decongestive Therapy Complex Decongestive Therapy

Eligibility Criteria

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Inclusion Criteria

* unilateral breast cancer with ipsilateral lumpectomy or mastectomy and lymph node dissection (sentinel biopsy or axillary dissection)
* stage II or III unilateral secondary upper extremity lymphedema (as defined by the International Society of Lymphology)
* girth ≥ 2 cm circumferential difference and/or volume ≥ 200 mL compared to the uninvolved upper extremity at any 4 cm segment
* able to commit to a long term follow-up schedule

Exclusion Criteria

* active cancer/metastatic cancer
* currently receiving or have plans for adjuvant radiation or chemotherapy
* pregnant
* presence of other extremity lymphedema (primary or secondary)
* pacemaker
* artificial joints in the upper quadrants
* renal failure
* arterial insufficiency
* congestive heart failure
* chronic inflammatory conditions
* history of deep vein thrombosis (DVT) in the lymphedematous upper extremity
* previous treatment with Low Level Laser (regardless of indication)
* medication(s) known to affect body fluid balance
* body mass index (BMI) \> 40 (morbid obesity)
Minimum Eligible Age

21 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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NYU Langone Health

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Teresa Denham, PT, MA

Role: PRINCIPAL_INVESTIGATOR

NYU Rusk Institute of Rehabilitation Medicine

Locations

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NYU Clinical Cancer Center

New York, New York, United States

Site Status

NYU Rusk Institute of Rehabilitation Medicine

New York, New York, United States

Site Status

Tisch Hospital

New York, New York, United States

Site Status

Countries

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United States

Other Identifiers

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10-00923

Identifier Type: -

Identifier Source: org_study_id

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