Intravenous Ferric Carboxymaltose (Ferinject) in Patients Undergoing Orthopaedic Surgery

NCT ID: NCT01345968

Last Updated: 2013-08-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE4

Total Enrollment

3 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-06-30

Study Completion Date

2013-02-28

Brief Summary

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The primary purpose of this study is to evaluate the safety and efficacy of preoperative intravenous ferric carboxymaltose in patients with anemia undergoing hip or knee replacement

Detailed Description

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Conditions

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Anemia Orthopedic Surgery High Risk of Blood Loss

Keywords

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anemia transfusion intravenous ferric carboxymaltose

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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NaCl 0.9%

Group Type PLACEBO_COMPARATOR

NaCl 0.9%

Intervention Type DRUG

iv administration of max. 50 ml in 30 minutes

Ferinject

Group Type EXPERIMENTAL

Ferinject 50 mg/ml

Intervention Type DRUG

iv administration of max. 50 ml (Dilution: 20 ml in 30 ml NaCl 0.9%) in 30 minutes

Interventions

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Ferinject 50 mg/ml

iv administration of max. 50 ml (Dilution: 20 ml in 30 ml NaCl 0.9%) in 30 minutes

Intervention Type DRUG

NaCl 0.9%

iv administration of max. 50 ml in 30 minutes

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* age \>= 18 years
* Patients scheduled to undergo hip or knee replacement
* 8 g/dl \< Hb \< 13 g/dl for men and 8 g/dl \< Hb \< 12 g/dl for women at screening (3-4 weeks prior to surgery)
* anemia
* signed written informed consent

Exclusion Criteria

* immunosuppressive or myelosuppressive therapy
* history of thromboembolic events
* a concurrent medical condition(s) that would prevent compliance or participation or jeopardize the health of the patient
* hypersensitivity to any component of the formulation
* transfusion within 1 month prior to study inclusion
* liver values 3 times higher than normal
* active severe infection/inflammation
* renal insufficiency
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Vifor Pharma

INDUSTRY

Sponsor Role collaborator

University Hospital Muenster

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Hugo K Van Aken, PhD, MD

Role: PRINCIPAL_INVESTIGATOR

Department of Anesthesia and Intensiv Care, University Hospital Muenster

Locations

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Charité Universitätsmedizin Berlin

Berlin, , Germany

Site Status

University Hospital Muenster

Münster, , Germany

Site Status

Countries

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Germany

Other Identifiers

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2010-024115-14

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

05-AnIt-09

Identifier Type: OTHER

Identifier Source: secondary_id

UKM10_0027

Identifier Type: -

Identifier Source: org_study_id