Innovative Tool to Increase Completion of Human Papillomavirus (HPV) Vaccine Series

NCT ID: NCT01343485

Last Updated: 2018-06-26

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

365 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-09-30

Study Completion Date

2012-10-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Planned Parenthood Federation of America's (PPFA) Medical Affairs Division will conduct a prospective, cluster randomized trial to determine which factors influence the acquisition of the second and third human papillomavirus (HPV) vaccine doses among young women ages 19 to 26. This descriptive and interventional study will provide data to assess impact of a computerized tool upon HPV vaccine series completion. The interventional aspect of this study includes determination of patient assistance and provider support programs applicable to each woman's situation as well as the implementation of a computer software system for customized patient reminders.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

GARDASIL Vaccination

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Control, standard care for HPV vaccine

Study participants in control sites will receive standard care for HPV vaccine administration and follow-up per PPFA protocol

Group Type NO_INTERVENTION

No interventions assigned to this group

Intervention, computer reminder system

Study participants in the intervention sites will receive standard care for HPV vaccine administration per PPFA protocol, reminder messages for subsequent vaccination appointments, and real-time determination of financial assistance for HPV vaccine.

Group Type EXPERIMENTAL

Computer reminder system

Intervention Type BEHAVIORAL

Intervention sites will receive computer kiosk with study specific software to assist in reminding study participants to return for HPV vaccine series

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Computer reminder system

Intervention sites will receive computer kiosk with study specific software to assist in reminding study participants to return for HPV vaccine series

Intervention Type BEHAVIORAL

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Female;
* Age 19-26;
* Fluent in English;
* Seeking services for anything except pregnancy or abortion on the day of the visit
* No previous vaccinations for HPV
* No contraindication for HPV vaccine (includes a severe allergic reaction to yeast, amorphous aluminum hydroxyphosphate sulfate, and polysorbate 80.)
* Access to phone, text, mail, email, or facebook
* Not wanting to become pregnant in the next 8 months;
* Not planning on moving from the area in the next 8 months
* Willing to be contacted for follow-up over the next 8 months.

Exclusion Criteria

* Women below 19 or above 26.
* Male
* Women who have one or more of HPV vaccination.
* Women who have a contraindication for HPV vaccine.
* Women who do not have access by phone, mail, email, Twitter or Facebook for follow up.
* Women who are not fluent in English
* Pregnant women or those intending on becoming pregnant during the study period.
* Women who will be moving from the area and unable to return for follow up over the course of the study (approximately 8 months).
* Severe mental impairment and unable to give Informed Consent.
Minimum Eligible Age

19 Years

Maximum Eligible Age

26 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Merck Sharp & Dohme LLC

INDUSTRY

Sponsor Role collaborator

Planned Parenthood Federation of America

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Johanna Morfesis

Director of Research

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Ashlesha Patel, MD, MPH

Role: PRINCIPAL_INVESTIGATOR

Planned Parenthood Federation of America, Inc.

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Planned Parenthood of Arizona

Glendale, Arizona, United States

Site Status

Planned Parenthood of Rocky Mountains

Arvada, Colorado, United States

Site Status

Planned Parenthood of Rocky Mountains

Denver, Colorado, United States

Site Status

Family Planning Clinic of the John H. Stroger Jr. Hospital of Cook County

Chicago, Illinois, United States

Site Status

Planned Parenthood of Central North Carolina

Chapel Hill, North Carolina, United States

Site Status

Planned Parenthood of North Carolina

Charlotte, North Carolina, United States

Site Status

Planned Parenthood Association of Utah

Ogden, Utah, United States

Site Status

Planned Parenthood Association of Utah

South Jordan, Utah, United States

Site Status

Planned Parenthood of Greater Northwest

Seattle, Washington, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

References

Explore related publications, articles, or registry entries linked to this study.

Centers for Disease Control and Prevention (CDC). Recommended adult immunization schedule--United States, 2011. MMWR Morb Mortal Wkly Rep. 2011 Feb 4;60(4):1-4. No abstract available.

Reference Type BACKGROUND
PMID: 21381442 (View on PubMed)

Chao C, Velicer C, Slezak JM, Jacobsen SJ. Correlates for completion of 3-dose regimen of HPV vaccine in female members of a managed care organization. Mayo Clin Proc. 2009 Oct;84(10):864-70. doi: 10.4065/84.10.864.

Reference Type BACKGROUND
PMID: 19797775 (View on PubMed)

Dempsey A, Cohn L, Dalton V, Ruffin M. Patient and clinic factors associated with adolescent human papillomavirus vaccine utilization within a university-based health system. Vaccine. 2010 Jan 22;28(4):989-95. doi: 10.1016/j.vaccine.2009.10.133. Epub 2009 Nov 17.

Reference Type BACKGROUND
PMID: 19925899 (View on PubMed)

Jain N, Euler GL, Shefer A, Lu P, Yankey D, Markowitz L. Human papillomavirus (HPV) awareness and vaccination initiation among women in the United States, National Immunization Survey-Adult 2007. Prev Med. 2009 May;48(5):426-31. doi: 10.1016/j.ypmed.2008.11.010. Epub 2008 Dec 6.

Reference Type BACKGROUND
PMID: 19100762 (View on PubMed)

Neubrand TP, Breitkopf CR, Rupp R, Breitkopf D, Rosenthal SL. Factors associated with completion of the human papillomavirus vaccine series. Clin Pediatr (Phila). 2009 Nov;48(9):966-9. doi: 10.1177/0009922809337534. Epub 2009 May 29. No abstract available.

Reference Type BACKGROUND
PMID: 19483128 (View on PubMed)

Orenstein WA, Mootrey GT, Pazol K, Hinman AR. Financing immunization of adults in the United States. Clin Pharmacol Ther. 2007 Dec;82(6):764-8. doi: 10.1038/sj.clpt.6100401. Epub 2007 Oct 31.

Reference Type BACKGROUND
PMID: 17971821 (View on PubMed)

Sandfort JR, Pleasant A. Knowledge, attitudes, and informational behaviors of college students in regard to the human papillomavirus. J Am Coll Health. 2009 Sep-Oct;58(2):141-9. doi: 10.1080/07448480903221368.

Reference Type BACKGROUND
PMID: 19892651 (View on PubMed)

Patel A, Stern L, Unger Z, Debevec E, Roston A, Hanover R, Morfesis J. Staying on track: a cluster randomized controlled trial of automated reminders aimed at increasing human papillomavirus vaccine completion. Vaccine. 2014 May 1;32(21):2428-33. doi: 10.1016/j.vaccine.2014.02.095. Epub 2014 Mar 13.

Reference Type DERIVED
PMID: 24631099 (View on PubMed)

Related Links

Access external resources that provide additional context or updates about the study.

https://www.plannedparenthood.org/

Planned Parenthood Federation of America

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

PPFA-Merck-38068

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Preparedness Study - HPV Vaccine
NCT01489527 COMPLETED NA
Usability of HPV Vaccine Reminders
NCT03987490 COMPLETED NA
Parents' HPV Stories
NCT06704308 NOT_YET_RECRUITING NA