Surveillance Trial to Evaluate a Shortened Infusion Time of Intravenous Ibuprofen

NCT ID: NCT01334944

Last Updated: 2023-07-05

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

150 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-06-30

Study Completion Date

2012-10-31

Brief Summary

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The primary objective of this study is to determine the safety of a single dose of intravenous ibuprofen administered over 5-10 minutes for the treatment of fever or pain in the hospital setting.

Detailed Description

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Conditions

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Pain Fever

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Intravenous ibuprofen

Intravenous ibuprofen (400 mg or 800 mg intravenous ibuprofen administered intravenously over 5-10 minutes) will be administered as a single dose during the 5-10 minute Treatment Period.

Group Type EXPERIMENTAL

Intravenous ibuprofen

Intervention Type DRUG

400 mg or 800 mg intravenous ibuprofen administered intravenously over 5-10 minutes

Interventions

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Intravenous ibuprofen

400 mg or 800 mg intravenous ibuprofen administered intravenously over 5-10 minutes

Intervention Type DRUG

Other Intervention Names

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Caldolor

Eligibility Criteria

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Inclusion Criteria

* Pain: Patients with baseline Visual Analog Scale assessment \>3, -and/or- Fever: Patients with temperature \>101°F.

Exclusion Criteria

1. Patients with inadequate IV access
2. Patients \<18 years of age
3. History or allergy or hypersensitivity to any component of intravenous ibuprofen, aspirin (or aspirin related products) or non-steroidal anti-inflammatory drug (NSAIDs)
4. Active hemorrhage or clinically significant bleeding
5. Pregnant or nursing
6. Patients in the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery
7. Inability to understand the requirements of the study, be willing to provide written informed consent (as evidenced by signature on an informed consent document approved by an Institutional Review Board \[IRB\]), and agree to abide by the study restrictions
8. Refusal to provide written authorization for use and disclosure of protected health information
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Cumberland Pharmaceuticals

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Art P Wheeler, M.D.

Role: STUDY_DIRECTOR

Cumberland Pharmaceuticals, Inc.

Locations

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UCSD

San Diego, California, United States

Site Status

Danbury

Danbury, Connecticut, United States

Site Status

University of Miami - Miller School of Medicine

Miami, Florida, United States

Site Status

Grady

Atlanta, Georgia, United States

Site Status

Beth Israel Deaconnes MC

Boston, Massachusetts, United States

Site Status

Columbia

New York, New York, United States

Site Status

The University of North Carolina Hospitals

Chapel Hill, North Carolina, United States

Site Status

Duke University Medical Center

Durham, North Carolina, United States

Site Status

The Moses H. Cone Memorial Hospital

Greensboro, North Carolina, United States

Site Status

Wake Forest University Baptist Medical Center

Winston-Salem, North Carolina, United States

Site Status

Fairview

Cleveland, Ohio, United States

Site Status

The Ohio State University Medical Center

Columbus, Ohio, United States

Site Status

Lankenau

Wynnewood, Pennsylvania, United States

Site Status

Countries

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United States

Other Identifiers

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CPI-CL-015

Identifier Type: -

Identifier Source: org_study_id

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