Study Evaluating The Efficacy Of A Novel Ibuprofen Formulation On Fever In Patients With An Uncomplicated Acute Infection

NCT ID: NCT01035346

Last Updated: 2012-08-21

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE3

Total Enrollment

16 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-01-31

Study Completion Date

2011-05-31

Brief Summary

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This single-dose trial will evaluate the efficacy of a novel ibuprofen formulation compared to placebo in patients with a fever due to an uncomplicated acute infection.

Detailed Description

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Conditions

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Infection

Keywords

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Fever antipyretic uncomplicated acute viral infection uncomplicated acute bacterial infections

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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A

Group Type EXPERIMENTAL

Ibuprofen

Intervention Type DRUG

Single dose of a novel ibuprofen formulation (equal to 400mg ibuprofen)

B

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Single dose of a placebo

Interventions

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Ibuprofen

Single dose of a novel ibuprofen formulation (equal to 400mg ibuprofen)

Intervention Type DRUG

Placebo

Single dose of a placebo

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Subjects diagnosed with a fever secondary to an uncomplicated acute viral or bacterial infection.
* Oral temperature measurement from 100 to 104 degrees Fahrenheit.
* Onset of fever 3 days or less.
* Otherwise good health.

Exclusion Criteria

* Fever secondary to a chronic underlying medical condition or serious infection.
* Currently taking antibiotics or antivirals.
* Currently taking any medication which may interfere with the assessment of fever.
* Pregnancy or breast-feeding.
* Any serious medical or psychiatric disorder.
Minimum Eligible Age

12 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pfizer

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

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Pfizer Investigational Site

Cypress, California, United States

Site Status

Pfizer Investigational Site

Westlake Village, California, United States

Site Status

Pfizer Investigational Site

Omaha, Nebraska, United States

Site Status

Pfizer Investigational Site

Pittsburgh, Pennsylvania, United States

Site Status

Pfizer Investigational Site

Salt Lake City, Utah, United States

Site Status

Countries

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United States

References

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Jayawardena S, Leyva R, Kellstein D. Safety of a novel formulation of ibuprofen sodium compared with standard ibuprofen and placebo. Postgrad Med. 2015 Jan;127(1):33-7. doi: 10.1080/00325481.2015.993268. Epub 2014 Dec 15.

Reference Type DERIVED
PMID: 25526232 (View on PubMed)

Related Links

Other Identifiers

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AH-09-12

Identifier Type: -

Identifier Source: org_study_id