Evaluation of Overall Compliance and Duration of Zomacton® Treatment With the Zomajet® Needle-free Device

NCT ID: NCT01306357

Last Updated: 2023-11-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

87 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-09-30

Study Completion Date

2011-11-30

Brief Summary

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The purpose of this strictly observational, prospective, longitudinal study is to evaluate with sufficient precision the rate of overall treatment compliance from one year to 3 years of follow-up of the patients.

Somatotropin is indicated in the long-term treatment of children with growth retardation related to a deficiency in secretion of growth hormone and in the long-term treatment of growth retardation related to Turner's syndrome confirmed by chromosomal analysis. These are the two indications of Zomacton® 4 mg and 10 mg injection solution.

The use of the Zomajet® needle-free device (Zomajet® 2 Vision, reserved for the administration of Zomacton® 4 mg or of the Zomajet® Vision X needle-free device, reserved for the administration of Zomacton® 10 mg), allows the product to be administered by percutaneous transjection (needle-free) and can be used by the child directly or by the family after an initial training.

In April 2004, the CEPP (Commission for the Evaluation of Products and Services) requested a follow-up of the cohort of patients using the Zomajet® 2 Vision system measuring the compliance and duration of use of the device.

The number of patients initiated on Zomacton treatment using the Zomajet® needle-free device is estimated to 30. Over a period of inclusion of 3 years, we therefore estimate that 90 patients will be treated. In the cohort studied the patients will be followed-up for 1 year at least and for 3 years at the maximum.

The rate of treatment compliance will be evaluated according to the ratio of the actual duration of administration over the total duration recommended by the physician during the observation period.

Detailed Description

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Conditions

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Turner's Syndrome Human Growth Hormone Deficiency

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Zomacton® with Zomajet® needle-free device

Zomacton® 4 mg delivered by percutaneous transjection (needle-free) using the Zomajet® 2 Vision device or Zomacton® 10 mg delivered by percutaneous transjection (needle-free) using the Zomajet® Vision X needle-free device.

Somatropin

Intervention Type DRUG

4 mg or 10 mg delivered by needle-free device

Interventions

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Somatropin

4 mg or 10 mg delivered by needle-free device

Intervention Type DRUG

Other Intervention Names

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human growth hormone Zomacton

Eligibility Criteria

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Inclusion Criteria

* Growth hormone deficiency
* Turner's syndrome

Exclusion Criteria

* Patients who do not meet the criteria in the treatment Information Sheet
Minimum Eligible Age

1 Year

Maximum Eligible Age

16 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ferring Pharmaceuticals

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Clinical Development Support

Role: STUDY_DIRECTOR

Ferring Pharmaceuticals

Locations

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Investigational site

Angers, , France

Site Status

Investigational site

Antibes Juan Les Pins, , France

Site Status

Investigational site

Bordeaux, , France

Site Status

Investigational site

Brive-la-Gaillarde, , France

Site Status

Investigational site

Hyères, , France

Site Status

Investigational site

Le Mans, , France

Site Status

Investigational site

Lille, , France

Site Status

Investigational site

Lisieux, , France

Site Status

Investigational site

Montivilliers, , France

Site Status

Investigational site

Montpellier, , France

Site Status

Investigational site

Nice, , France

Site Status

Investigational site

Nieul-sur-Mer, , France

Site Status

Investigational site

Paris, , France

Site Status

Investigational site

Puyricard, , France

Site Status

Investigational site

Tarbes, , France

Site Status

Investigational site

Toulon, , France

Site Status

Investigational site

Toulouse, , France

Site Status

Countries

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France

Other Identifiers

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RZO 01

Identifier Type: -

Identifier Source: org_study_id

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