A Follow-up Study to Assess Long-term Immunogenicity and Safety of NicVAX/Placebo as an Aid to Smoking Cessation

NCT ID: NCT01304810

Last Updated: 2012-05-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-01-31

Study Completion Date

2011-08-31

Brief Summary

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The purpose of the study is to obtain two year follow up data for subjects that received six vaccinations of NicVAX in prior phase III studies. No treatment will be administered. Anti-nicotine antibody levels and safety data will be collected.

Detailed Description

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This study will follow subjects that participated in the NicVAX phase III studies for a second year. These predecessor studies, Nabi-4514 (NCT#00836199) and Nabi-4515 (NCT#01102114) evaluate the efficacy and safety of 6 vaccinations of NicVAX or placebo as an aid to smoking cessation. The two phase III studies are one year in duration, and subjects who complete these studies are eligible to enroll in Nabi-4522. As the phase III studies are ongoing, subject assignment to NicVAX or placebo will remain masked. No intervention will be administered in Nabi-4522. Subjects will be followed for immunogenicity (anti-nicotine antibody level)and for safety.

Conditions

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Smoking Cessation Nicotine Dependence

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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NicVAX

NicVAX vaccine

NicVAX vaccine

Intervention Type BIOLOGICAL

Prior treatment with NicVAX in Nabi-4514 or Nabi-4515. No intervention in Nabi-4522.

Placebo vaccine

Placebo vaccine

Placebo

Intervention Type BIOLOGICAL

Prior treatment with Placebo in Nabi-4514 or Nabi-4515. No intervention in Nabi-4522.

Interventions

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NicVAX vaccine

Prior treatment with NicVAX in Nabi-4514 or Nabi-4515. No intervention in Nabi-4522.

Intervention Type BIOLOGICAL

Placebo

Prior treatment with Placebo in Nabi-4514 or Nabi-4515. No intervention in Nabi-4522.

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Subjects who agree and sign consent to participate in this follow-up study.
* Subjects randomized and completed month 12 of the Nabi-4514 or Nabi-4515 study.
* Subjects who have received a total of 6 injections in Nabi-4514 or Nabi-4515.

Exclusion Criteria

* Anticipated inability to follow the study protocol through-out the study period.
* Known history of any condition or factor judged by the investigator to preclude participation in the study or which might hinder compliance or failure to sign informed consent.
* Subjects who intend to receive, or who are receiving an Investigational New Drug/Device during the study.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Nabi Biopharmaceuticals

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Medical Director

Role: STUDY_DIRECTOR

Nabi Biopharmaceuticals

Locations

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NicVAX Investigator

Newport Beach, California, United States

Site Status

NicVAX Investigator

San Diego, California, United States

Site Status

NicVAX Investigator

Miami, Florida, United States

Site Status

NicVAX Investigator

Boise, Idaho, United States

Site Status

NicVAX Investigator

Lexington, Kentucky, United States

Site Status

NicVAX Investigator

College Park, Maryland, United States

Site Status

NicVAX Investigator

Boston, Massachusetts, United States

Site Status

NicVAX Investigator

Rochester, New York, United States

Site Status

NicVAX Investigator

Raleigh, North Carolina, United States

Site Status

NicVAX Investigator

Portland, Oregon, United States

Site Status

NicVAX Investigator

Norfolk, Virginia, United States

Site Status

NicVAX Investigator

Seattle, Washington, United States

Site Status

Countries

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United States

Other Identifiers

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Nabi-4522

Identifier Type: -

Identifier Source: org_study_id

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