A Second Study of NicVAX/Placebo as an Aid for Smoking Cessation

NCT ID: NCT01102114

Last Updated: 2012-05-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

1000 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-03-31

Study Completion Date

2011-11-30

Brief Summary

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The purpose of this study is to evaluate NicVAX as an aid to smoking cessation for long term abstinence.

Detailed Description

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Conditions

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Smoking Cessation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Placebo Vaccine

Group Type PLACEBO_COMPARATOR

Placebo Vaccine

Intervention Type BIOLOGICAL

Placebo vaccine given 6 times over 6 months

NicVAX Vaccine

Group Type EXPERIMENTAL

NicVAX Vaccine

Intervention Type BIOLOGICAL

NicVAX vaccine given 6 times over 6 months

Interventions

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NicVAX Vaccine

NicVAX vaccine given 6 times over 6 months

Intervention Type BIOLOGICAL

Placebo Vaccine

Placebo vaccine given 6 times over 6 months

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Current smoker who smokes at least 10 cigarettes a day during the past year and wants to quit smoking.
* Smokers who are in good general health.

Exclusion Criteria

* Prior exposure to NicVAX or any other nicotine vaccine.
* Use of systemic steroids.
* Cancer or cancer treatment in the last 5 years.
* HIV infection.
* History of drug or alcohol abuse or dependence within 12 months.
* Significant cardiovascular, hepatic, renal, psychiatric and/or respiratory disease.
* Inability to fulfill all visits for approximately 52 weeks.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Nabi Biopharmaceuticals

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Medical Monitor

Role: STUDY_DIRECTOR

Nabi Biopharmaceuticals

Locations

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NicVAX Investigator

Encino, California, United States

Site Status

NicVAX Investigator

Los Alamitos, California, United States

Site Status

NicVAX Investigator

Denver, Colorado, United States

Site Status

NicVAX Investigator

New Haven, Connecticut, United States

Site Status

NicVAX Investigator

Brooksville, Florida, United States

Site Status

NicVAX Investigator

Orlando, Florida, United States

Site Status

NicVAX Investigator

Pembroke Pines, Florida, United States

Site Status

NicVAX Investigator

Tampa, Florida, United States

Site Status

NicVAX Investigator

Indianapolis, Indiana, United States

Site Status

NicVAX Investigator

Wichita, Kansas, United States

Site Status

NicVAX Investigator

Metairie, Louisiana, United States

Site Status

NicVAX Investigator

Annapolis, Maryland, United States

Site Status

NicVAX Investigator

Milford, Massachusetts, United States

Site Status

NicVAX Investigator

East Lansing, Michigan, United States

Site Status

NicVAX Investigator

Rochester, Minnesota, United States

Site Status

NicVAX Investigator

Jackson, Mississippi, United States

Site Status

NicVAX Investigator

Omaha, Nebraska, United States

Site Status

NicVAX Investigator

Buffalo, New York, United States

Site Status

NicVAX Investigator

Cincinnati, Ohio, United States

Site Status

NicVAX Investigator

Mt. Pleasant, South Carolina, United States

Site Status

NicVAX Investigator

Knoxville, Tennessee, United States

Site Status

NicVAX Investigator

Nashville, Tennessee, United States

Site Status

NicVAX Investigator

Houston, Texas, United States

Site Status

NicVAX Investigator

Salt Lake City, Utah, United States

Site Status

NicVAX Investigator

Charleston, West Virginia, United States

Site Status

Countries

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United States

Other Identifiers

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Nabi-4515

Identifier Type: -

Identifier Source: org_study_id

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