Role of the Gut Sweet Taste Receptor in the Secretion of Satiation Peptides

NCT ID: NCT01302574

Last Updated: 2011-02-24

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 16 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2010-01-31
• Study Completion Date: 2010-06-30

Brief Summary

The purpose of this study is to determine the functional significance of sweet taste receptors in the secretion of gastrointestinal (GI) satiation peptides by using a specific sweet taste receptor antagonist to block sweet taste perception in the gastrointestinal tract.

Detailed Description

There is strong evidence that taste signaling mechanisms identified in the oral epithelium also operate in the gut. It is suggested that open-type enteroendocrine cells directly sense nutrient via alpha-gustducin coupled taste receptors to modulate the secretion of glucagon like peptide-1 (GLP-1) and peptide YY (PYY). Several nutrient responsive G-protein coupled receptors have been identified in the human gut, including the sweet taste responsive T1R2/T1R3 heterodimer, the amino acid/umami responsive T1R1/T1R3 as well as GPR120 for unsaturated long-chain free fatty acids. The functional significance of sweet taste receptors in mixed liquid meal-stimulated secretion of GLP-1 and PYY will be determined by intragastric infusion of a 500 mL mixed liquid meal with or without lactisole (450 ppm)in a double blind, 2-way crossover trial including 16 healthy subjects.

Conditions

Taste Disorder, Secondary, Sweet

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: QUADRUPLE

Study Groups

mixed liquid meal

500 mL mixed liquid meal + 50 mg 13C-sodium-acetate

Group Type: PLACEBO_COMPARATOR

lactisole

Intervention Type: DIETARY_SUPPLEMENT

Lactisole-liquid meal: Lactisole (450 ppm) will be mixed with a liquid meal. Liquid meal only: The comparator will be the liquid meal alone.

mixed liquid meal + lactisole

500 mL mixed liquid meal + 50 mg 13C-sodium-acetate + 450 ppm lactisole

Group Type: ACTIVE_COMPARATOR

lactisole

Intervention Type: DIETARY_SUPPLEMENT

Lactisole-liquid meal: Lactisole (450 ppm) will be mixed with a liquid meal. Liquid meal only: The comparator will be the liquid meal alone.

Interventions

lactisole

Lactisole-liquid meal: Lactisole (450 ppm) will be mixed with a liquid meal. Liquid meal only: The comparator will be the liquid meal alone.

Intervention Type: DIETARY_SUPPLEMENT

Other Intervention Names

Dietary supplement

Eligibility Criteria

Inclusion Criteria

• healthy subjects
• BMI of 19.0-24.5
• age 18-40 years old
• stable body weight for at least 3 month

Exclusion Criteria

• smoking
• substance abuse
• regular intake of medication
• medical or psychiatric illness
• gastrointestinal disorders or food allergies

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 40 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University Hospital, Basel, Switzerland

OTHER

Sponsor Role: lead

Responsible Party

Department of Gastroenterology, University Hospital Basel, Basel, Switzerland

Principal Investigators

Christoph Beglinger, MD

Role: PRINCIPAL_INVESTIGATOR

Phase 1 Research Unit, University Hospital Basel

Locations

University Hospital Basel, Phase 1 Research Unit

Basel, , Switzerland

Countries

Switzerland

Other Identifiers

EKBB 69/04.02

Identifier Type: -

Identifier Source: org_study_id