Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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WITHDRAWN
PHASE4
INTERVENTIONAL
Brief Summary
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Elucidate the action and therapeutic value of 5-FU in Keloid scar treatment
Identify the genetic link with Keloid scar formation.
Quantify the psychological/social impact in keloid scarring patients
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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5-Fluorouracil
Patients with small keloidal scars to have intralesional 5FU injected
5- fluorouracil
5mg of 5FU injected per 1cm square, at 6 week intervals for 30 weeks = 6 sessions
Radiotherapy
Large keloid scars undergo extralesional excision and radiotherapy
radiotherapy
after complete excision of keloid they have a single session of radiotherapy
TAC
Triamcinolone
TAC 10mg in 1ml injected intralesional
Interventions
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5- fluorouracil
5mg of 5FU injected per 1cm square, at 6 week intervals for 30 weeks = 6 sessions
radiotherapy
after complete excision of keloid they have a single session of radiotherapy
Triamcinolone
TAC 10mg in 1ml injected intralesional
Eligibility Criteria
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Inclusion Criteria
* Keloid scarring present.
* Able to understand and give informed consent.
* Patients giving informed consent to donate keloidal or non-affected skin when that is redundant after a procedure (i.e. BBR, Abdominoplasty).
* Patients with a strong familial pedigree of keloid scar formation.
Exclusion Criteria
* Infected lesion
* Pregnant or planning pregnancy in the near future
* Lactating (Breast Feeding)
* Abnormal renal or liver function tests
* Atrophic scars
* Patient under 18 years of age
* Immunocompromised
* OR immunosuppressed
18 Years
85 Years
ALL
No
Sponsors
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Queen Mary University of London
OTHER
Responsible Party
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Locations
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Barts and the London NHS Trust
London, UK, United Kingdom
Countries
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Related Links
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Related Info
Other Identifiers
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KS001
Identifier Type: -
Identifier Source: org_study_id
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