Incorporating Avocados in Meals

NCT ID: NCT01271829

Last Updated: 2014-03-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-01-31

Study Completion Date

2012-09-30

Brief Summary

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The purpose of this study is to examine the effect of incorporating avocados in meals on post-ingestion glycemic index, insulin response, sensations of satiety and on appetite-related gastrointestinal peptide and hormone release. Also the effect of consuming avocado containing meals on the caloric intake of participants in subsequent eating episodes will be explored.

Each subject will participate in one intervention for one day, wait one or two weeks, come for another intervention, wait one or two weeks and come for a final intervention- three in total. Participants will be randomly assigned to one of six treatment sequences. Postprandial response to the control and two avocado-containing test meals will be assessed and compared using a 3 x 3 single blind cross-over design. The Subjects will be between 25 and 60 years old, female or male, with a BMI of 23 to 32, stable weight, no sports involvement, non-smoking and not dependent on caffeine. Thirty subjects will be recruited.

Detailed Description

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Conditions

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Satiety Glycemic Index Insulin Gastrointestinal Peptides and Hormones

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Blinding Strategy

SINGLE

Investigators

Study Groups

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Control

While on the control arm subjects will be given a meal with no avocado.

Group Type NO_INTERVENTION

No interventions assigned to this group

Avocado supplement

While on the avocado supplement arm subjects will be given a meal in which a given amount of calories will be replaced by calories contributed by avocados.

Group Type ACTIVE_COMPARATOR

Avocado supplement

Intervention Type DIETARY_SUPPLEMENT

Calories from avocados replace calories of the control lunch

Avocado included

While on the avocado included arm subjects will be given a meal in which the calories of avocado will be added to the calories of the control meal.

Group Type ACTIVE_COMPARATOR

Avocado included

Intervention Type DIETARY_SUPPLEMENT

Calories from avocados will be added to calories from the control lunch

Interventions

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Avocado supplement

Calories from avocados replace calories of the control lunch

Intervention Type DIETARY_SUPPLEMENT

Avocado included

Calories from avocados will be added to calories from the control lunch

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* 23-60 years old
* BMI 23-32
* Stable weight for 6 months
* Live or work near Loma Linda University

Exclusion Criteria

* Smoker
* Heavy involvement in sports
* Dependent on caffeine
Minimum Eligible Age

23 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Hass Avocado Board

OTHER

Sponsor Role collaborator

Loma Linda University

OTHER

Sponsor Role lead

Responsible Party

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Joan Sabate,DrPH, MD

Chair, Department of Nutrition

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Joan Sabaté, MD, DrPH

Role: PRINCIPAL_INVESTIGATOR

Loma Linda University

Locations

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Loma Linda University, Department of Nutrition

Loma Linda, California, United States

Site Status

Countries

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United States

References

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Wien M, Haddad E, Oda K, Sabate J. A randomized 3x3 crossover study to evaluate the effect of Hass avocado intake on post-ingestive satiety, glucose and insulin levels, and subsequent energy intake in overweight adults. Nutr J. 2013 Nov 27;12:155. doi: 10.1186/1475-2891-12-155.

Reference Type RESULT
PMID: 24279738 (View on PubMed)

Related Links

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Other Identifiers

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5100220

Identifier Type: -

Identifier Source: org_study_id

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