Gait Analysis and Neuromuscular Function After Primary Total Hip Replacement

NCT ID: NCT01229293

Last Updated: 2012-09-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

39 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-02-28

Study Completion Date

2011-11-30

Brief Summary

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This study is conducted at Odense University Hospital(OUH) in collaboration with Institute of Clinical Biomechanics and Sport Science, University of Southern Denmark and Clinical Institute, University of Southern Denmark

Aim: To evaluate the effect of implant design on postoperative total leg muscle function recovery and gait in hip replacement patients.

Design: A prospective randomized controlled clinical trial where patients are randomized into (A) total hip arthroplasty surgery (THA) or (B) resurfacing total hip replacement surgery (RTHA). Pre-surgery assessment and follow-up will be conducted at 8, 26 and 52 wks post-surgery.

Detailed Description

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The project consist of three substudies:

* Determination of test-retest reliability and agreement of specific mechanical muscle function variables for the patients of interest.
* Evaluate the effect of implant design on postoperative mechanical muscle recovery
* Evaluate the effect of implant design on postoperative gait

Conditions

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Osteoarthritis

Keywords

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Mechanical muscle function Muscle strength Hip replacement Osteoarthritis Hip arthroplasty

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Resurfacing Total Hip Arthroplasty

A hip replacement that leaves most of the underlying bone intact and mimics the natural biomechanical features of the hip joint. Articular surface replacement ASR, DePuy posterolateral approach used (RTHA)

Group Type EXPERIMENTAL

Articular Surface Replacement (ASR)

Intervention Type PROCEDURE

Articular surface replacement, DePuy, posterolateral approach used

Standard Total Hip Arthroplasty (THA)

A standard 28 mm head uncemented THA

Group Type ACTIVE_COMPARATOR

Standard Total Hip Arthroplasty (THA)

Intervention Type PROCEDURE

Device: Biomet 28mm

Interventions

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Articular Surface Replacement (ASR)

Articular surface replacement, DePuy, posterolateral approach used

Intervention Type PROCEDURE

Standard Total Hip Arthroplasty (THA)

Device: Biomet 28mm

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Primary arthrosis

Exclusion Criteria

* Osteoporosis, (T-score \< 2.5 SD) of proximal femur
* BMI \> 35
* Severe acetabulum dysplasia (AP centre edge \< 15-20°)
* Femur anteversion \> 25°
* Severe caput deformity
* Leg length discrepancy \> 1 cm
* Off-set problems
* Earlier fracture of the ipsilateral proximal femur
* Rheumatoid arthritis
* Neuromuscular or vascular disease
Minimum Eligible Age

40 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ministry of the Interior and Health, Denmark

OTHER_GOV

Sponsor Role collaborator

The Danish Rheumatism Association

OTHER

Sponsor Role collaborator

Odense University Hospital

OTHER

Sponsor Role collaborator

University of Southern Denmark

OTHER

Sponsor Role lead

Responsible Party

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Carsten Jensen

PhD-fellow

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Søren Overgaard, Prof., MD., PhD

Role: STUDY_CHAIR

Odense University Hospital

Locations

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Orthopaedic Research Unit, Dept. of Orthopaedic Surgery and Traumatology, Odense University Hospital, Inst. of Clinical Research - University of Southern Denmark

Odense, , Denmark

Site Status

Countries

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Denmark

References

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Jensen C, Rosenlund S, Nielsen DB, Overgaard S, Holsgaard-Larsen A. The use of the Gait Deviation Index for the evaluation of participants following total hip arthroplasty: An explorative randomized trial. Gait Posture. 2015 Jun;42(1):36-41. doi: 10.1016/j.gaitpost.2015.02.009. Epub 2015 Apr 28.

Reference Type DERIVED
PMID: 25957650 (View on PubMed)

Jensen C, Aagaard P, Overgaard S. Recovery in mechanical muscle strength following resurfacing vs standard total hip arthroplasty - a randomised clinical trial. Osteoarthritis Cartilage. 2011 Sep;19(9):1108-16. doi: 10.1016/j.joca.2011.06.011. Epub 2011 Jun 28.

Reference Type DERIVED
PMID: 21749928 (View on PubMed)

Other Identifiers

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VF20050133-2

Identifier Type: -

Identifier Source: org_study_id