Trial of OTD70DERM® in Radio-dermatitis Induced by Radiotherapy-Erbitux®

NCT ID: NCT01228565

Last Updated: 2015-03-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

76 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-08-31

Study Completion Date

2014-05-31

Brief Summary

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The aim of this randomized trial is to compare the rate of radio-dermatitis grade 2+ (NCI-CTC V3.0) in patients receiving radiotherapy+Erbitux+placebo versus in patients receiving radiotherapy+Erbitux+OTD70DERM® for the treatment of head and neck carcinoma.

Detailed Description

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Conditions

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Head and Neck Carcinoma

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Placebo

Radiotherapy+Erbitux+Placebo

Group Type PLACEBO_COMPARATOR

Radiotherapy + Erbitux® + placebo

Intervention Type OTHER

3D radiotherapy 70 Gy / 7 weeks (no IRMT); Erbitux once a week, 1 week before radiotherapy and during radiotherapy ; Placebo local application, once a day, every day during the radiotherapy

OTD70DERM

Radiotherapy+Erbitux+OTD70DERM®

Group Type EXPERIMENTAL

Radiotherapy+Erbitux+OTD70DERM

Intervention Type OTHER

3D radiotherapy 70 Gy / 7 weeks (no IRMT); Erbitux once a week, 1 week before radiotherapy and during radiotherapy ; OTD70DERM local application, once a day, every day during the radiotherapy

Interventions

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Radiotherapy + Erbitux® + placebo

3D radiotherapy 70 Gy / 7 weeks (no IRMT); Erbitux once a week, 1 week before radiotherapy and during radiotherapy ; Placebo local application, once a day, every day during the radiotherapy

Intervention Type OTHER

Radiotherapy+Erbitux+OTD70DERM

3D radiotherapy 70 Gy / 7 weeks (no IRMT); Erbitux once a week, 1 week before radiotherapy and during radiotherapy ; OTD70DERM local application, once a day, every day during the radiotherapy

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Head and neck carcinoma treated by radiotherapy (70Gy) plus Erbitux

Exclusion Criteria

* IMRT; Concomitant chemotherapy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Groupe Oncologie Radiotherapie Tete et Cou

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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CHI Creteil

Créteil, , France

Site Status

Centre de Forcilles

Ferolles Attily, , France

Site Status

CLCC Nantes

Nantes, , France

Site Status

CHU Pitie Salpetriere

Paris, , France

Site Status

Institut Gustave Roussy

Villejuif, , France

Site Status

Countries

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France

Other Identifiers

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GORTEC 2009-01

Identifier Type: -

Identifier Source: org_study_id

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