Program evaLuating the Autoimmune Disease iNvEstigational Drug cT-p13 in AS Patients(PLANETAS)

NCT ID: NCT01220518

Last Updated: 2013-03-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

257 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-10-31

Study Completion Date

2012-06-30

Brief Summary

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This study is the trial to demonstrate how our product is similar to remicade by comparing the results of blood samples in active Ankylosing Spondylitis patients.

Detailed Description

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Conditions

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Ankylosing Spondylitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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CT-P13

infliximab

Group Type ACTIVE_COMPARATOR

Infliximab

Intervention Type DRUG

Infliximab 5mg/kg is going to be administered for both arm as a 2-hour infusion per dose.

Remicade

infliximab

Group Type ACTIVE_COMPARATOR

Infliximab

Intervention Type DRUG

Infliximab 5mg/kg is going to be administered for both arm as a 2-hour infusion per dose.

Interventions

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Infliximab

Infliximab 5mg/kg is going to be administered for both arm as a 2-hour infusion per dose.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* diagnosed with active ankylosing spondylitis
* BASDAI score ≥ 4 and visual analogue scale(VAS) score of spinal pain ≥ 4

Exclusion Criteria

* have total ankylosing of spine
* have allergies to infliximab
* serious infection
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Celltrion

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Won Park, M.D., Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Inha University Hospital

Locations

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Inha University Hostpital

Incheon, , South Korea

Site Status

Countries

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South Korea

References

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Eser A, Reinisch W, Schreiber S, Ahmad T, Boulos S, Mould DR. Increased Induction Infliximab Clearance Predicts Early Antidrug Antibody Detection. J Clin Pharmacol. 2021 Feb;61(2):224-233. doi: 10.1002/jcph.1732. Epub 2020 Sep 9.

Reference Type DERIVED
PMID: 32905628 (View on PubMed)

Park W, Yoo DH, Jaworski J, Brzezicki J, Gnylorybov A, Kadinov V, Sariego IG, Abud-Mendoza C, Escalante WJ, Kang SW, Andersone D, Blanco F, Hong SS, Lee SH, Braun J. Comparable long-term efficacy, as assessed by patient-reported outcomes, safety and pharmacokinetics, of CT-P13 and reference infliximab in patients with ankylosing spondylitis: 54-week results from the randomized, parallel-group PLANETAS study. Arthritis Res Ther. 2016 Jan 20;18:25. doi: 10.1186/s13075-016-0930-4.

Reference Type DERIVED
PMID: 26795209 (View on PubMed)

Other Identifiers

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CT-P13 1.1

Identifier Type: -

Identifier Source: org_study_id

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