An Extension Study to Demonstrate the Equivalence of Long-Term Efficacy and Safety of CT-P13 in Patients With Ankylosing Spondylitis Who Were Treated With Infliximab (Remicade or CT-P13) in Study CT-P13 1.1

NCT ID: NCT01571206

Last Updated: 2013-07-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

174 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-03-31

Study Completion Date

2013-05-31

Brief Summary

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This open-label, single-arm, multicenter, multiple single-dose intravenous (IV) infusion, efficacy, and safety extension study of the Phase 1 Study CT-P13 1.1 is designed to assess the long-term efficacy and safety of multiple doses of CT-P13.

Detailed Description

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Conditions

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Ankylosing Spondylitis

Keywords

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AS Biosimilar

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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CT-P13

infliximab

Group Type ACTIVE_COMPARATOR

Infliximab

Intervention Type BIOLOGICAL

CT-P13 (5mg/kg) administered as a 2-hour IV infusion per dose

Interventions

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Infliximab

CT-P13 (5mg/kg) administered as a 2-hour IV infusion per dose

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Patient who has completed the scheduled visits, including the End-of-Study Visit, in Study CT-P13 1.1
* Patient who has not had any major protocol violation in Study CT-P13 1.1

Exclusion Criteria

* Patient who has been withdrawn from Study CT-P13 1.1 for any reason
* Patient who, at the time of providing informed consent, has any ongoing medical issues such as serious adverse events(SAEs) or intolerance issues that mean continuation in this extension study could be detrimental to their health, in the option of the investigator
* Patient who plans to participate in a study with an investigational drug during the period of this extension study
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Celltrion

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Won Park, M.D., Ph.D.

Role: STUDY_DIRECTOR

Inha University Hospital

Locations

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Inha University Hospital

Incheon, , South Korea

Site Status

Countries

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South Korea

References

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Park W, Yoo DH, Miranda P, Brzosko M, Wiland P, Gutierrez-Urena S, Mikazane H, Lee YA, Smiyan S, Lim MJ, Kadinov V, Abud-Mendoza C, Kim H, Lee SJ, Bae Y, Kim S, Braun J. Efficacy and safety of switching from reference infliximab to CT-P13 compared with maintenance of CT-P13 in ankylosing spondylitis: 102-week data from the PLANETAS extension study. Ann Rheum Dis. 2017 Feb;76(2):346-354. doi: 10.1136/annrheumdis-2015-208783. Epub 2016 Apr 26.

Reference Type DERIVED
PMID: 27117698 (View on PubMed)

Other Identifiers

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2011-004572-11

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

CT-P13 1.3

Identifier Type: -

Identifier Source: org_study_id