Importance of the GH/IGF-1 Axis for Human Substrate and Energy Metabolism During Calorie Restriction
NCT ID: NCT01209429
Last Updated: 2011-09-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
10 participants
INTERVENTIONAL
2010-09-30
2011-09-30
Brief Summary
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Detailed Description
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On the molecular level the specific relations are not fully understood. This study will investigate the possible connection between SITR1 and the relation to the GH/IGF-I axis and STAT5b in healthy men. The participant will fast 42 and 12 hours respectively, and have GH or placebo infusions. The design is a classical 2x2 design and will be randomized.
Knowledge of the interactions between calorie restriction, SIRT1, STAT5b and the GH/IGF-I axis will apply important information about the relations between aging, energy metabolism and metabolic disturbances.
Conditions
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Study Design
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RANDOMIZED
FACTORIAL
BASIC_SCIENCE
SINGLE
Study Groups
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42 hour fast/GH infusion
GH hormone infusion
Norditropin 30 ng/kg/min
42 hour fast
The participant will be fasting 42 hours prior to the start of the study day, drinking water is allowed
42 hour fast/Placebo infusion
42 hour fast
The participant will be fasting 42 hours prior to the start of the study day, drinking water is allowed
12 hour fast/GH infusion
GH hormone infusion
Norditropin 30 ng/kg/min
12 hour fast
12 hour fast will be used as a control scenario to 42 hour fast
12 hour fast/Placebo infusion
12 hour fast
12 hour fast will be used as a control scenario to 42 hour fast
Interventions
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GH hormone infusion
Norditropin 30 ng/kg/min
42 hour fast
The participant will be fasting 42 hours prior to the start of the study day, drinking water is allowed
12 hour fast
12 hour fast will be used as a control scenario to 42 hour fast
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* age \>18
Exclusion Criteria
* alcohol drug abuse
* malign disease: current or previous
18 Years
70 Years
MALE
Yes
Sponsors
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University of Aarhus
OTHER
Responsible Party
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Birgitte Nellemann
MD PhD student
Principal Investigators
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Jens Otto L Jørgensen, Professor
Role: PRINCIPAL_INVESTIGATOR
University Hospital of Aarhus
Locations
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University Hospital of Aarhus, Norrebrogade
Aarhus, , Denmark
Countries
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References
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Hjelholt AJ, Lee KY, Arlien-Soborg MC, Pedersen SB, Kopchick JJ, Puri V, Jessen N, Jorgensen JOL. Temporal patterns of lipolytic regulators in adipose tissue after acute growth hormone exposure in human subjects: A randomized controlled crossover trial. Mol Metab. 2019 Nov;29:65-75. doi: 10.1016/j.molmet.2019.08.013. Epub 2019 Aug 20.
Nellemann B, Vendelbo MH, Nielsen TS, Bak AM, Hogild M, Pedersen SB, Bienso RS, Pilegaard H, Moller N, Jessen N, Jorgensen JO. Growth hormone-induced insulin resistance in human subjects involves reduced pyruvate dehydrogenase activity. Acta Physiol (Oxf). 2014 Feb;210(2):392-402. doi: 10.1111/apha.12183. Epub 2013 Nov 22.
Other Identifiers
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M-20100150
Identifier Type: -
Identifier Source: org_study_id
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