Evaluation of an Oral Nutritional Supplement Containing AN777

NCT ID: NCT01191125

Last Updated: 2013-03-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

331 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-02-28

Study Completion Date

2012-09-30

Brief Summary

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To evaluate the effect of an experimental oral nutritional supplement containing AN777 compared to another oral nutritional supplement in a malnourished, elderly population.

Detailed Description

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Conditions

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Malnutrition Sarcopenia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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medical food with AN777

Group Type EXPERIMENTAL

medical food with AN777

Intervention Type OTHER

Two(220 mL)servings every day for six months

oral nutritional formula

Group Type ACTIVE_COMPARATOR

oral nutritional formula

Intervention Type OTHER

Two (220 mL) servings daily for six months

Interventions

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medical food with AN777

Two(220 mL)servings every day for six months

Intervention Type OTHER

oral nutritional formula

Two (220 mL) servings daily for six months

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

Subject (male or female) is \> or equal to 65 and \< or equal to 90 years of age

Subject is ambulatory

Subject has a Subjective Global Assessment of B or C

Subject has gait speed \<0.8 m/s AND/OR low hand-grip strength

Subject has Class 1 or Class 2 sarcopenia

Subject agrees to refrain from starting a resistance exercise program

Exclusion Criteria

Subject has type 1 or type 2 diabetes

Subject has inflammatory disease with elevated high sensitivity C-reactive protein

Subject has renal function impairment

Subject reports gastrointestinal disorder (severe chronic diarrhea, nausea, vomiting) that would preclude ingestion of the study product; an obstruction of the gastrointestinal tract, inflammatory bowel disease; short bowel syndrome or other major gastrointestinal disease

Subject reports of current active malignant disease or other significant medical diagnoses.

Subject reports a history of allergy to any of the ingredients in the study products

Subject reports currently taking medications/dietary supplements/substances that could profoundly modulate metabolism or weight.
Minimum Eligible Age

65 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Abbott Nutrition

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Vikkie Mustad, PhD

Role: STUDY_CHAIR

Abbott Nutrition

Locations

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University of Alabama, Brimingham

Birmington, Alabama, United States

Site Status

Radiant Research, Inc

Santa Rosa, California, United States

Site Status

Provident Clinical Research

Addison, Illinois, United States

Site Status

Radiant Research, Inc

Chicago, Illinois, United States

Site Status

Radiant Research, Inc.

Overland Park, Kansas, United States

Site Status

Creighton University

Omaha, Nebraska, United States

Site Status

Radiant Research, Inc

Cincinnati, Ohio, United States

Site Status

Radiant Research, Inc.

Dallas, Texas, United States

Site Status

ZNA St. Elisabeth

Antwerp, , Belgium

Site Status

Catholic University of Rome

Rome, , Italy

Site Status

University of Verona

Verona, , Italy

Site Status

Althian - Research Management Center

Monterrey, Nuevo León, Mexico

Site Status

NSZOZ Unica CR

Dąbrówka, , Poland

Site Status

Mazowieckie Centrum Badan Klinicznych S.C..

Grodzisk Mazowiecki, , Poland

Site Status

Tomasz Dabrowski Slaskie Centrum

Katowice, , Poland

Site Status

Centrum Medyczne Osteomed

Warsaw, , Poland

Site Status

Hospital Clinic de Barcelona

Barcelona, , Spain

Site Status

Hospital General Universitario Gregorio Maranon

Madrid, , Spain

Site Status

Insituto Provincial de Rehabilitacion

Madrid, , Spain

Site Status

Hospital Universitario Ramon y Cajal

Madrid, , Spain

Site Status

University Hospitals, WHO

Geneva, , Switzerland

Site Status

Imperial College Healthcare NHS Trust

Charing Cross, London, United Kingdom

Site Status

University of Nottingham Medical School,

Nottingham, , United Kingdom

Site Status

Countries

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United States Belgium Italy Mexico Poland Spain Switzerland United Kingdom

References

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Cramer JT, Cruz-Jentoft AJ, Landi F, Hickson M, Zamboni M, Pereira SL, Hustead DS, Mustad VA. Impacts of High-Protein Oral Nutritional Supplements Among Malnourished Men and Women with Sarcopenia: A Multicenter, Randomized, Double-Blinded, Controlled Trial. J Am Med Dir Assoc. 2016 Nov 1;17(11):1044-1055. doi: 10.1016/j.jamda.2016.08.009.

Reference Type DERIVED
PMID: 27780567 (View on PubMed)

Hickson M. Nutritional interventions in sarcopenia: a critical review. Proc Nutr Soc. 2015 Nov;74(4):378-86. doi: 10.1017/S0029665115002049. Epub 2015 Apr 29.

Reference Type DERIVED
PMID: 25923603 (View on PubMed)

Other Identifiers

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BK94

Identifier Type: -

Identifier Source: org_study_id

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