Study of Tocotrienol Absorption and Distribution Under Different Fat Status

NCT ID: NCT01185769

Last Updated: 2010-08-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-09-30

Study Completion Date

2009-09-30

Brief Summary

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Despite the emerging interest in tocotrienols, the absorption of tocotrienols in humans remains unclear especially with different fat diets.This study aimed at evaluating the absorption and distribution of tocotrienols in plasma and lipoproteins in associations with high and low fat diets. Different fat level will affect the absorption and distribution of tocotrienols

Detailed Description

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There is a possibility that the absorption and distribution of tocotrienols may occur differently compared with tocopherols, especially under different fat status

Conditions

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Absorption

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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High fat

500 mg of tocotrienol will be administered at single dose after consumption of high fat diet

Group Type EXPERIMENTAL

Tocotrienol

Intervention Type DIETARY_SUPPLEMENT

500 mg of tocotrienol will be administered after consumption of high fat diet

Low fat

500 mg of tocotrienol will be administered at single dose after consumption of low fat diet

Group Type EXPERIMENTAL

Tocotrienol

Intervention Type DIETARY_SUPPLEMENT

500 mg of tocotrienol will be administered after consumption of low fat diet

Interventions

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Tocotrienol

500 mg of tocotrienol will be administered after consumption of high fat diet

Intervention Type DIETARY_SUPPLEMENT

Tocotrienol

500 mg of tocotrienol will be administered after consumption of low fat diet

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* male aged 22-25
* body mass index 18.5 \< X \< 30 kg/m2
* plasma cholesterol \< 5.2 mmol/L,
* TAG \< 1.7 mmol/L

Exclusion Criteria

* history of cardiovascular disease
* diabetic
* body mass index \< 18.5 or \> 30 kg/m2
* plasma cholesterol \> 5.2 mmol/L,
* TAG \> 1.7 mmol/L
* hypertension
* currently taking Vitamin E supplement
* current use of medication
* smoking.
Minimum Eligible Age

22 Years

Maximum Eligible Age

25 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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University of Malaya

OTHER

Sponsor Role collaborator

Malaysia Palm Oil Board

OTHER_GOV

Sponsor Role lead

Responsible Party

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Malaysian Palm Oil Board

Principal Investigators

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Weng-Yew Wong, Bsc

Role: PRINCIPAL_INVESTIGATOR

Malaysia Palm Oil Board

Locations

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Malaysian Palm Oil Board

Bangi, Selangor, Malaysia

Site Status

Countries

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Malaysia

Other Identifiers

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PD141/09

Identifier Type: -

Identifier Source: org_study_id

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