Radiologic Features of Invasive Pulmonary Aspergillosis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

130 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-01-31

Study Completion Date

2010-02-28

Brief Summary

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Invasive pulmonary aspergillosis (IPA) is an opportunistic infection that primarily affects recipients of solid organ transplants (SOTs) and patients with chemotherapy- induced neutropenia.Although both of these populations are at high risk for IPA, they differ with regards to the specific defects in host defense mechanisms that increase their risk for IPA. Chemotherapy- induced neutropenia is the principal defect affecting patients with hematologic malignancies, whereas transplant recipients tend to have dysfunctional T cells and phagocytes, as a result of immunosuppressive drug therapy. Thus, the patterns of IPA-related infection and inflammation may differ according to the type of underlying immune defect. Although the clinical and radiological features of IPA in patients with neutropenia have been extensively studied, little is known about the characteristics of IPA in SOT recipients. The investigators therefore compared the IPA- related clinical and radiological findings in SOT recipients with those of neutropenic patients.

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Detailed Description

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Conditions

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Hematologic Disease Solid Organ Transplantation

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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SOT recipients

solid organ transplant recipients with invasive pulmonary aspergillosis

No interventions assigned to this group

Hematologic disease

Hematologic disease patients with invasive pulmonary aspergillosis

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* IPA cases with solid organ transplant recipients and hematologic disease patients
* proven and probable invasive pulmonary aspergillosis by modified EORTC/MSG criteria