Longer-term Recurrence Rates in Patients With Bladder Cancer After Hexvix (Cysview)Fluorescence Cystoscopy/TURB

NCT ID: NCT01166230

Last Updated: 2019-04-09

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

551 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-06-30

Study Completion Date

2010-12-31

Brief Summary

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The study is intended to investigate whether the improved initial detection and resection of bladder cancer lesions in patients with non-muscle invasive bladder cancer with Hexvix (Cysview) fluorescence cystoscopy/TURB will lead to a longer-term reduction in recurrences compared to standard white light cystoscopy/TURB.

Detailed Description

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A previously completed pivotal clinical study PC B305/04 demonstrated reduced recurrence rates for patients with papillary bladder cancer who underwent Hexvix (Cysview) and white light cystoscopy and transurethral resection (TURB) of the bladder compared to patients who underwent white light cystoscopy and TURB alone.

The present study is intended to investigate whether the improved initial detection and resection of bladder cancer lesions in patients with non-muscle invasive bladder cancer with Hexvix (Cysview) fluorescence cystoscopy/TURB will also lead to a longer-term reduction in recurrences compared to standard white light cystoscopy/TURB.

No safety data was collected.

Conditions

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Bladder Cancer

Study Design

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Observational Model Type

OTHER

Study Time Perspective

RETROSPECTIVE

Study Groups

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Patients with Ta/T1, randomized to white light cystoscopy

Patients with non-invasive papillary bladder cancer (Ta/T1), enrolled in the previously completed pivotal phase III study PC B305/04 who were followed for recurrence.

No interventions assigned to this group

Patients with Ta/T1 randomized to Hexvix cystoscopy

Patients with non-invasive papillary bladder cancer (Ta/T1), enrolled in the previously completed pivotal phase III study PC B305/04 who were followed for recurrence.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patients of study PC B305/04 with Ta or T1, that were followed for recurrence are eligible to be included in this study.

Exclusion Criteria

* Patient died during clinical study PC B305/04
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Photocure

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Herbert Barton Grossman, MD

Role: PRINCIPAL_INVESTIGATOR

The University of Texas MD Anderson Cancer Center

Locations

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Stanford Cancer Center, Department of Urology

Stanford, California, United States

Site Status

V.A. Medical Center

Gainesville, Florida, United States

Site Status

University of Miami School of Medicine

Miami, Florida, United States

Site Status

South Florida Clinical Research Center, Inc.

Pembroke Pines, Florida, United States

Site Status

The Emory Clinic, Dept of Urology

Atlanta, Georgia, United States

Site Status

Boston University School of Medicine

Boston, Massachusetts, United States

Site Status

Urologic Clinical Research Unit, Gonda 7102, Mayo Clinic Rochester

Rochester, Minnesota, United States

Site Status

Hackensack University Medical Center

Hackensack, New Jersey, United States

Site Status

Mount Sinai Medical Center, Department of Urology

New York, New York, United States

Site Status

URMC

Rochester, New York, United States

Site Status

Thomas Jefferson Medical College, Department of Neurology

Philadelphia, Pennsylvania, United States

Site Status

Vanderbilt University Medical Center, Department of Urologic Surgery

Nashville, Tennessee, United States

Site Status

Baylor College of Medicine, Scott Department of Urology

Houston, Texas, United States

Site Status

The University of Texas MD Anderson cancer center

Houston, Texas, United States

Site Status

AKH, Klinik für Urologie der Universität Wien

Vienna, , Austria

Site Status

Kingston General Hospital

Kingston, Ontario, Canada

Site Status

CHUQ Hotel-Dieu de Quebec

Québec, , Canada

Site Status

University Clinic of Giessen, Department of Urology

Giessen, , Germany

Site Status

Klinikum der Universität München-Großhardern, Urologische Klinik und Poliklinik

München, , Germany

Site Status

Urologische Klinik München-Planegg

Planegg, , Germany

Site Status

Akadem. Lehrkrankenhaus der Uni Regensburg, Klinik für Urologie

Regensburg, , Germany

Site Status

Universitätsklinik Tuebingen, Universitätsklinik für Urologie

Tübingen, , Germany

Site Status

Department of Urology, Academic Medical Center, University of Amsterdam

Amsterdam, , Netherlands

Site Status

Department of Urology, UMC St. Radboud

Nijmegen, , Netherlands

Site Status

Countries

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United States Austria Canada Germany Netherlands

Related Links

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http://www.bcan.org/

Bladder Cancer Advocacy Network (BCAN)

Other Identifiers

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PC B305/E10

Identifier Type: -

Identifier Source: org_study_id

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