Mixed Strain H. Pylori Infection in Patients Who Have Problems With Eradication of H. Pylori

NCT ID: NCT01164969

Last Updated: 2010-07-19

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 10 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2008-11-30
• Study Completion Date: 2010-07-31

Brief Summary

The purpose of this study is to determine whether mixed H. pylori strain infection is the reason for eradication failure during treatment of H. pylori infection. The investigators present the results got from extensive sampling of biopsy samples taken from individuals diagnosed with H. pylori connected disease. The investigators were looking for individuals that were not able to eradicate H. pylori although they had susceptibility testing tailored antibiotic therapy. On their control visit after 2 months they presented again with H. pylori although at their first visit they had H. pylori isolated from biopsy sample sensitive to all antibiotics prescribed. Multi Locus Sequence Typing (MLST) was used to prove the sequence type of H. pylori and E test was used to determine susceptibility of H. pylori to antibiotics.

Conditions

H. Pylori Eradication Failure

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: PROSPECTIVE

Study Groups

H. pylori eradication failure

People who are not able to eradicate H. pylori although the appropriate antibiotic therapy taken.

Antibiotics to which H. pylori can not develope resistance

Intervention Type: DRUG

Amoxicillin, metronidazole and tetracyclin as primary drugs to treat H. pylori infection in duration of 10 days.

Interventions

Antibiotics to which H. pylori can not develope resistance

Amoxicillin, metronidazole and tetracyclin as primary drugs to treat H. pylori infection in duration of 10 days.

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• People who have H. pylori sensitive to all antibiotics before therapy and and do not eradicate H. pylori after appropriate antibiotic therapy.

Exclusion Criteria

• People who did not eradicate H. pylori because of primary resistance to antibiotics.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Institute of microbiology and immunology, Slovenia

UNKNOWN

Sponsor Role: collaborator

University Medical Centre Ljubljana

OTHER

Sponsor Role: lead

Principal Investigators

Alojz Ihan, MD. PhD

Role: STUDY_DIRECTOR

Institute of mircobiology and immunology, Slovenia

Locations

Institute of microbiology and immunology

Ljubljana, , Slovenia

Countries

Slovenia

Other Identifiers

IMI2010-2

Identifier Type: -

Identifier Source: org_study_id