Study to Assess the Effect of Food on Combination Dapagliflozin/Metformin Tablet in Healthy Volunteers

NCT ID: NCT01156246

Last Updated: 2012-06-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

18 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-06-30

Study Completion Date

2010-08-31

Brief Summary

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The purpose of this study is to determine whether treatment with a fixed dose combination dapagliflozin/metformin tablet is affected by food.

Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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1

Dapagliflozin/metformin tablet, high fat, high calorie breakfast day 1, visit 2, 7-14 days wash-out, Dapagliflozin/metformin tablet, fasting conditions day 1, visit 3.

Group Type EXPERIMENTAL

Dapagliflozin/Metformin

Intervention Type DRUG

oral fixed dose combination tablet 5 mg Dapagliflozin / 1000 mg Metformin given on day 1 at visit 2 and 3.

2

Dapagliflozin/metformin tablet, fasting conditions day 1, visit 2, 7-14 days wash-out, Dapagliflozin/metformin tablet, high fat, high calorie breakfast day 1, visit 3.

Group Type EXPERIMENTAL

Dapagliflozin/Metformin

Intervention Type DRUG

oral fixed dose combination tablet 5 mg Dapagliflozin / 1000 mg Metformin given on day 1 at visit 2 and 3.

Interventions

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Dapagliflozin/Metformin

oral fixed dose combination tablet 5 mg Dapagliflozin / 1000 mg Metformin given on day 1 at visit 2 and 3.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Healthy
* BMI 18-30 kg/m2

Exclusion Criteria

* History of clinically significant illness.
* History of alcohol or drug abuse
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Bristol-Myers Squibb

INDUSTRY

Sponsor Role collaborator

AstraZeneca

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Aslak Rautio

Role: PRINCIPAL_INVESTIGATOR

Quintiles Hermelinen AB, Varvsgatan 53, SE-972 33 Luleå, Sweden

Wolfgang Kühn

Role: PRINCIPAL_INVESTIGATOR

Quintiles AB, Global Phase I Services, Strandbodgatan 1, SE-753 23 Uppsala, Sweden

Mirjana Kujacic

Role: STUDY_CHAIR

AZ Global Clinical Development, Pepparedsleden 1, 431 83 Mölndal, 431 83 Mölndal

Locations

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Research Site

Luleå, , Sweden

Site Status

Countries

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Sweden

Other Identifiers

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D1691C00005

Identifier Type: -

Identifier Source: org_study_id

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