Mechanisms of Stroke in Intracranial Stenosis

NCT ID: NCT01152944

Last Updated: 2012-02-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-07-31

Study Completion Date

2011-12-31

Brief Summary

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The objective of this SAMMPRIS-affiliated study is to understand the mechanisms the mechanisms that underlie ischemic stroke recurrence in high-grade intracranial atherosclerotic disease in order to determine predictors of recurrent stroke. MoSIS will evaluate 6 specific mechanisms of stroke in the medically-treated SAMMPRIS cohort: decreased antegrade flow, progression of stenosis, decreased proximal collateral flow, decreased distal collateral flow, impaired cerebrovascular reserve, and artery-to-artery embolism.

Detailed Description

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Conditions

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Stroke

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Enrolled in the medical arm of SAMMPRIS, signed consent

Exclusion Criteria

* For QMRA testing: contraindications to MRI; for TCD testing, abscence of ultrasonographic windows.
Minimum Eligible Age

30 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Institute of Neurological Disorders and Stroke (NINDS)

NIH

Sponsor Role collaborator

Jose Romano, MD

OTHER

Sponsor Role lead

Responsible Party

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Jose Romano, MD

Associate Professor of Neurology. Director of Cerebrovascular Division

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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University of Miami

Miami, Florida, United States

Site Status

Countries

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United States

Other Identifiers

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1R01NS069938-01

Identifier Type: NIH

Identifier Source: secondary_id

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1R01NS069938-01

Identifier Type: NIH

Identifier Source: org_study_id

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