Moyamoya Disease Biomarkers in Patients With Intracranial Atherosclerotic Stroke

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

400 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-01-31

Study Completion Date

2019-12-31

Brief Summary

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The aim of this study is to investigate the proportion of patients with moyamoya disease among the patients who were diagnosed as having intracranial atherosclerotic stroke. To do this, biomarkers (gene and imaging) for moyamoya disease are tested and follow up angiography are performed during follow up (in selected patients).

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Detailed Description

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1. Purpose Both moyamoya disease (MMD) and intracranial atherosclerotic stenosis (ICAS) are more prevalent in Asians than in Westerners, although the reason for the race-ethnic differences is unsettled. It is possible that patients with adult-onset MMD were misclassified as having ICAS, which may in part explain the high prevalence of intracranial atherosclerosis in Asians. It is important to differentiation between these two diseases because MMD and ICAS have differential therapeutic strategies (surgical revascularization in MMD vs. the use of antithrombotics/statins and stenting in ICAS). The ring finger 213 (RNF213) was recently identified as a susceptibility gene for MMD in East Asians. Characteristic high-resolution (HR) MRI findings of MMD and ICAS have recently been reported. The aim of this study is to investigate the proportion of patients with moyamoya disease among the patients who were diagnosed as having intracranial atherosclerotic stroke. To do this, biomarkers (gene and imaging) for moyamoya disease are tested and follow up angiography are performed during follow up (in selected patients).
2. Conditions: Stroke, intracranial occlusive lesion
3. Intervention: None
4. Study period: Jan 22, 2014 \~ Dec 31, 2016
5. Study design: Observational model Time perspective: Retrospective-Prospective

Conditions

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Moyamoya Disease Intracranial Atherosclerotic Stroke Intracranial Steno-occlusive Disease

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

OTHER

Study Groups

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Intracranial atherosclerotic stroke

No interventions assigned to this group

Moyamoya disease

No interventions assigned to this group

Healthy controls

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

1. Intracranial atherosclerotic stroke

* Patients with age over 20 years
* Patients with focal neurological deficits presented within 7 days of symptom onset
* Patients with acute ischemic lesions on diffusion-weighted image (DWI)
* Patients with stenosis on the relevant intracranial vessels (distal ICA and/ or M1)
2. Moyamoya disease

* Patients with age over 20 years
* Patients who performed conventional angiography
* Patients who are diagnosed as having either definite or probable Moyamoya disease
3. Healthy subjects

* Subjects with age over 20 years
* Subjects with no history of cerebrovascular disease

Exclusion Criteria

* Patients with extracranial stenosis more than 50%
* Patients with potential sources of cardio-aortic embolism
* Patients with moderate to severe renal disease
* Pregnancy or lactation
* Patients with short life expectancy

Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes