Comparative Analysis of Intra-articular Injection of Steroid and/or Sodium Hyaluronate in Adhesive Capsulitis

NCT ID: NCT01144533

Last Updated: 2013-12-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-06-30

Study Completion Date

2013-12-31

Brief Summary

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The purpose of this study is to compare the efficacy of intra-articular steroid injection, sodium hyaluronate injection, a combination of the two, and placebo in the treatment of adhesive capsulitis of the shoulder.

Detailed Description

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Conditions

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Adhesive Capsulitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Isotonic saline

Group Type PLACEBO_COMPARATOR

isotonic saline injection into the glenohumeral joint

Intervention Type PROCEDURE

* Total volume of injection drugs: 8ml
* isotonic saline 4ml + telebrix(contrast media) 4ml
* The number of injections : only once during the study period
* Injection site : glenohumeral joint
* Material : 22-gauze spinal needle
* Anteroposterior, lateral, and axial arthrography after injection was performed to determine accuracy and patterns of the injection.

Steroid

Group Type EXPERIMENTAL

steroid injection into the glenohumeral joint

Intervention Type PROCEDURE

* Total volume of injection drugs: 8ml
* triamcinolone(40mg)1ml + isotonic saline 3ml + telebrix(contrast media)4ml
* The number of injections : only once during the study period
* Injection Site : glenohumeral joint
* Material : 22-gauze spinal needle
* Anteroposterior, lateral, and axial arthrography after injection was performed to determine accuracy and patterns of the injection.

Hyaluronate

Group Type EXPERIMENTAL

sodium hyaluronate injection into the glenohumeral joint

Intervention Type PROCEDURE

* Total volume of injection drugs: 8ml
* sodium hyaluronate 2ml + isotonic saline 2ml + telebrix(contrast media)4ml
* The number of injections : only once during the study period
* Injection Site : glenohumeral joint
* Material : 22-gauze spinal needle
* Anteroposterior, lateral, and axial arthrography after injection was performed to determine accuracy and patterns of the injection.

Steroid + Hyaluronate

Group Type EXPERIMENTAL

steroid and hyaluronate injection into the glenohumeral joint

Intervention Type PROCEDURE

* Total volume of injection drugs: 8ml
* triamcinolone(40mg)1ml + sodium hyaluronate 2ml + isotonic saline 1ml + telebrix(contrast media)4ml
* The number of injections : only once during the study period
* Injection Site : glenohumeral joint
* Material : 22-gauze spinal needle
* Anteroposterior, lateral, and axial arthrography after injection was performed to determine accuracy and patterns of the injection.

Interventions

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isotonic saline injection into the glenohumeral joint

* Total volume of injection drugs: 8ml
* isotonic saline 4ml + telebrix(contrast media) 4ml
* The number of injections : only once during the study period
* Injection site : glenohumeral joint
* Material : 22-gauze spinal needle
* Anteroposterior, lateral, and axial arthrography after injection was performed to determine accuracy and patterns of the injection.

Intervention Type PROCEDURE

steroid injection into the glenohumeral joint

* Total volume of injection drugs: 8ml
* triamcinolone(40mg)1ml + isotonic saline 3ml + telebrix(contrast media)4ml
* The number of injections : only once during the study period
* Injection Site : glenohumeral joint
* Material : 22-gauze spinal needle
* Anteroposterior, lateral, and axial arthrography after injection was performed to determine accuracy and patterns of the injection.

Intervention Type PROCEDURE

sodium hyaluronate injection into the glenohumeral joint

* Total volume of injection drugs: 8ml
* sodium hyaluronate 2ml + isotonic saline 2ml + telebrix(contrast media)4ml
* The number of injections : only once during the study period
* Injection Site : glenohumeral joint
* Material : 22-gauze spinal needle
* Anteroposterior, lateral, and axial arthrography after injection was performed to determine accuracy and patterns of the injection.

Intervention Type PROCEDURE

steroid and hyaluronate injection into the glenohumeral joint

* Total volume of injection drugs: 8ml
* triamcinolone(40mg)1ml + sodium hyaluronate 2ml + isotonic saline 1ml + telebrix(contrast media)4ml
* The number of injections : only once during the study period
* Injection Site : glenohumeral joint
* Material : 22-gauze spinal needle
* Anteroposterior, lateral, and axial arthrography after injection was performed to determine accuracy and patterns of the injection.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* clinical diagnosis : Adhesive Capsulitis of the Shoulder
* defining of adhesive capsulitis

* the presence of shoulder pain
* limitation of both active and passive movements of the glenohumeral joint of ≥25% in at list 2 directions(abduction,flexion,external rotation,internal rotation), as compared with the contralateral shoulder
* duration : symptomatic for \< 1 year

Exclusion Criteria

* bilateral symptoms
* uncontrolled diabetes mellitus
* overt hypothyroidism or hyperthyroidism
* previous shoulder surgery
* previous glenohumeral joint injection within recent 6months
* trauma to the shoulder the last six months that required hospital care
* neurological symptoms
* allergy to injection material
* secondary adhesive capsulitis
* systemic inflammatory ds including rheumatoid arthritis
* degenerative arthritis of shoulder joint
* infectious arthritis of shoulder joint
* dislocation of shoulder joint
* blood coagulation disease
* rotator cuff tear
* serious mental illness
* pregnancy
* fracture in shoulder lesion
* CVA
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Seoul National University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Hyunchul Jo

Assistant Professor, SMG-SNU Boramae Medical Center.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Chris H. Jo, M.D., Ph.D

Role: PRINCIPAL_INVESTIGATOR

Joint & Spine Center, SMG-SNU Boramae Medical Center, Department of Orthopedic Surgery, Seoul National University College of Medicine

Locations

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Joint & Spine Center, SMG-SNU Boramae Medical Center, Department of Orthopedic Surgery, Seoul National University College of Medicine

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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BRM-10-01

Identifier Type: -

Identifier Source: org_study_id