Pathogenesis of Primary Spontaneous Pneumothorax

NCT ID: NCT01135004

Last Updated: 2010-06-02

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 30 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2010-03-31
• Study Completion Date: 2013-02-28

Brief Summary

Primary spontaneous pneumothorax most commonly occurs in young, tall, lean males. The estimated recurrence rate is 23-50% after the first episode and increases to 60% after the second pneumothorax. The pathogenesis of this benign disease remains unclear. Generally, rupture of the emphysematous change or blebs in the apex of the lung is considered as the cause of pneumothorax. The main purpose of this study is to investigate the molecular pathogenesis of blebs formation or emphysematous change of the lung in these young, healthy patients.

Detailed Description

Primary spontaneous pneumothorax most commonly occurs in young, tall, lean males. The estimated recurrence rate is 23-50% after the first episode and increases to 60% after the second pneumothorax. The pathogenesis of this benign disease remains unclear. Generally, rupture of the emphysematous change or blebs in the apex of the lung is considered as the cause of pneumothorax. The main purpose of this study is to investigate the molecular pathogenesis of blebs formation or emphysematous change of the lung in these young, healthy patients. The blebs resected from the pneumothorax patients will be used for RNA and protein levels analyses. The adjacent normal lung tissue will be used as a control for comparison.

Conditions

Pneumothorax

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Pneumothorax patients

Primary spontaneous pneumothorax patients undergoing thoracoscopic bullectomy

Thoracoscopic bullectomy

Intervention Type: PROCEDURE

Thoracoscopic wedge resection of the diseased lung

Interventions

Thoracoscopic bullectomy

Thoracoscopic wedge resection of the diseased lung

Intervention Type: PROCEDURE

Other Intervention Names

Video-assisted thoracic surgery (VATS)

Eligibility Criteria

Inclusion Criteria

• Age between 14 and 40 years
• Spontaneous pneumothorax
• Underwent bullectomy of the lung

Exclusion Criteria

• With underlying lung disease

• Minimum Eligible Age: 14 Years
• Maximum Eligible Age: 40 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

National Taiwan University Hospital, Yun-Lin Branch

OTHER

Sponsor Role: collaborator

National Science and Technology Council, Taiwan

OTHER_GOV

Sponsor Role: collaborator

National Taiwan University Hospital

OTHER

Sponsor Role: lead

Responsible Party

National Taiwan University Hospital

Principal Investigators

Yung-Chie Lee, MD, PhD

Role: STUDY_CHAIR

National Taiwan University Hospital

Locations

National Taiwan University Hospital

Taipei, Taiwan, Taiwan

Site Status: RECRUITING

Countries

Taiwan

Central Contacts

Jin-Shing Chen, MD, PhD

Role: CONTACT

chenjs@ntu.edu.tw

886-2-23123456 ext. 65178

Facility Contacts

Jin-Shing Chen, MD, PhD

Role: primary

chenjs@ntu.edu.tw

886-2-23123456 ext. 65178

References

Ayed AK, Chandrasekaran C, Sukumar M. Video-assisted thoracoscopic surgery for primary spontaneous pneumothorax: clinicopathological correlation. Eur J Cardiothorac Surg. 2006 Feb;29(2):221-5. doi: 10.1016/j.ejcts.2005.11.005. Epub 2005 Dec 20.

Reference Type: BACKGROUND

PMID: 16376095 (View on PubMed)

Other Identifiers

200912060R

Identifier Type: -

Identifier Source: org_study_id