The Influence of Anterior Chamber Fluid Mediators on the Success Rate of Trabeculectomy

NCT ID: NCT01115218

Last Updated: 2018-11-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

62 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-10-31

Study Completion Date

2012-03-31

Brief Summary

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The aim of the study is to investigate whether it is possible to predict the success of trabeculectomy in patients with glaucoma through the examination of mediators of wound healing in anterior chamber fluid. The success rate of trabeculectomy with mitomycin C in the literature is about 75%. This leads on the question why 25% of the patients received trabeculectomy are not sufficient treated and have not a long-term IOP reduction. Precisely this question is to be examined by the study.

Detailed Description

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Conditions

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Glaucoma Trabeculectomy Wound Healing

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Glaucoma patients

Trabeculectomy

Intervention Type PROCEDURE

Trabeculectomy with mitomycin C

Interventions

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Trabeculectomy

Trabeculectomy with mitomycin C

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* patients with glaucoma with a trabeculectomy required
* 60 eyes of 60 patients, The ratio of female / male is not involved.
* Eye pressure under local therapy: 20mmHg and above (corrected with pachymetry table).
* age of at least 18 years

* less than 50yl anterior chamber fluid could be collected during the operation.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Cologne

OTHER

Sponsor Role lead

Responsible Party

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Arno Hueber

Arno Hueber

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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University Eye Hospital, University of Cologne

Cologne, North Rhine-Westphalia, Germany

Site Status

Countries

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Germany

Other Identifiers

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MeVeTra-2009

Identifier Type: -

Identifier Source: org_study_id

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