Multidrug Resistance After Trabeculectomy With Mitomycin C

NCT ID: NCT00449631

Last Updated: 2007-03-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Brief Summary

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We investigate whether mitomycin C treatment during previous filtration surgery induces P-glycoprotein expression.

Detailed Description

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Despite the adjuvant use of mitomycin C during trabeculectomy, short-term and long-term failures still occur. We investigate whether mitomycin C treatment during previous trabeculectomy induces P-glycoprotein expression. Expression of P-glycoprotein is analysed in surgically removed Tenon tissue using immunohistochemistry.

Conditions

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Glaucoma Trabeculectomy

Study Design

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Study Time Perspective

OTHER

Eligibility Criteria

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Inclusion Criteria

* patients with planned trabeculectomy for elevated eye pressure
* one third of patients without previous trabeculectomy
* two thirds of patients with previous trabeculectomy (one third with and one third without the use of mitomycin C)

Exclusion Criteria

* patients not requiring surgery
* patients with planned surgery for elevated eye pressure other than trabeculectomy
Minimum Eligible Age

8 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Cologne

OTHER

Sponsor Role lead

Principal Investigators

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Arno Hueber, MD

Role: PRINCIPAL_INVESTIGATOR

University of Cologne

Locations

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The University Hospital of Cologne

Cologne, , Germany

Site Status

Countries

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Germany

References

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Hueber A, Esser JM, Kociok N, Welsandt G, Luke C, Roters S, Esser PJ. Mitomycin C induces multidrug resistance in glaucoma surgery. Graefes Arch Clin Exp Ophthalmol. 2008 Feb;246(2):297-304. doi: 10.1007/s00417-007-0695-1. Epub 2007 Oct 13.

Reference Type DERIVED
PMID: 17934748 (View on PubMed)

Other Identifiers

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Multidrug Resistance

Identifier Type: -

Identifier Source: org_study_id

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