Longitudinal Investigation of Hippocampal Function and Morphology in Acute Lymphatic Leukemia (ALL) Patients Treated With Chemotherapy
NCT ID: NCT01111396
Last Updated: 2010-04-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
10 participants
OBSERVATIONAL
2010-02-28
Brief Summary
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Clinical trials had shown that chemotherapy and brain radiation lead to cognitive dysfunction. However, the exact mechanisms underlying this phenomenon are still unidentified.
The aim of our study is to investigate, whether the inhibition of adult neural stem cell proliferation in the hippocampus by intrathecal chemotherapy and/or cerebral radiation is responsible for treatment induced memory deficits. We will investigate patients suffering from acute lymphatic leukaemia (ALL) that receive prophylactic intrathecal chemotherapy and brain irradiation. The study represents a longitudinal investigation including a virtual "humanized" version of the morris-water-maze to test hippocampus dependent spatial memory, as well as MR-imaging for morphological (volumetry) and biochemical (spectroscopy) data.
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Detailed Description
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Conditions
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Study Design
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CASE_ONLY
PROSPECTIVE
Study Groups
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Patient with ALL under chemotherapy
This group consists of patients with initial diagnosis of acute lymphatic leukemia (ALL), who are enrolled into the GMALL 2003 chemotherapy study. There is no change of the initial GMALL 2003 treatment protocol for the present study.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Treatment within the German Multicenter Adult ALL (GMALL 2003) therapy study
* Age 18 to 40 years
* Eligibility for performing study procedure
* Informed consent
Exclusion Criteria
* Present contraindication for MRI investigation (e.g. pacemaker)
18 Years
40 Years
ALL
No
Sponsors
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Martin-Luther-Universität Halle-Wittenberg
OTHER
Technische Universität Dresden
OTHER
Responsible Party
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Dresden University of Technology
Principal Investigators
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Alexander Storch, MD
Role: PRINCIPAL_INVESTIGATOR
Technische Universität Dresden
Locations
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Dresden University of Technology University Hospital
Dresden, , Germany
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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EK153052009
Identifier Type: -
Identifier Source: org_study_id
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