LOC387715/HTRA1 Variants in Polypoidal Choroidal Vasculopathy in a Korean Population
NCT ID: NCT01108250
Last Updated: 2011-08-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
215 participants
INTERVENTIONAL
2010-04-30
2011-08-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
SINGLE
Study Groups
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polypoidal choroidal vasculopathy
patients with polypoidal choroidal vasculopathy
LOC387715/HTRA1 genotyping
Genomic DNA was extracted from whole blood by standard methods. Genotyping was performed using SNP Genotyping Assays.
control
control group with no polypoidal choroidal vasculopathy
LOC387715/HTRA1 genotyping
Genomic DNA was extracted from whole blood by standard methods. Genotyping was performed using SNP Genotyping Assays.
Interventions
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LOC387715/HTRA1 genotyping
Genomic DNA was extracted from whole blood by standard methods. Genotyping was performed using SNP Genotyping Assays.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* polyp-like terminal aneurysmal dilations with or without branching vascular networks in indocyanine green angiography and subretinal reddish-orange protrusions corresponding to polyp-like lesions
* individuals without retinal diseases and without any signs of polypoidal choroidal vasculopathy or age-related macular degeneration on the bases of comprehensive ophthalmic examination results
Exclusion Criteria
Control group
60 Years
ALL
Yes
Sponsors
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Kyungpook National University Hospital
OTHER
Responsible Party
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Dong Ho Park
clinical professor
Principal Investigators
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In Taek Kim, M.D.
Role: PRINCIPAL_INVESTIGATOR
Kyungpook National University Hospital
Locations
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In Taek Kim
Daegu, Kyungsangpookdo, South Korea
Countries
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References
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Gotoh N, Nakanishi H, Hayashi H, Yamada R, Otani A, Tsujikawa A, Yamashiro K, Tamura H, Saito M, Saito K, Iida T, Matsuda F, Yoshimura N. ARMS2 (LOC387715) variants in Japanese patients with exudative age-related macular degeneration and polypoidal choroidal vasculopathy. Am J Ophthalmol. 2009 Jun;147(6):1037-41, 1041.e1-2. doi: 10.1016/j.ajo.2008.12.036. Epub 2009 Mar 9.
Related Links
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genetics home reference
MedlinePlus related topics
Other Identifiers
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LOC387715/HTRA1
Identifier Type: -
Identifier Source: org_study_id
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