Developing and Testing a Model to Identify Preventive Vision Loss Among Older Patients in General Practice

NCT ID: NCT07015034

Last Updated: 2025-06-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

460 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-05-15

Study Completion Date

2027-07-15

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

In this cohort study, the investigators will test vision screenings in Danish general practice for patients over 70 years of age with minimum one chronic condition. The main outcome is detection of vision impairment and secondary outcome is detection of conditions needing ophthalmologic follow-up but not presenting vision impairment at present time.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Introduction: The number of people living with visual impairment is increasing. Visual impairment causes loss in quality of life and reduce self-care abilities. The burden of disease is heavy for people experiencing visual impairment and their relatives. The severity and progression of age-related eye diseases are dependent on the time of detection and treatment options, making timely access to healthcare critical in reducing visual impairment. General practice plays a key role in public health by managing preventive healthcare, diagnostics and treatment of chronic conditions. General practitioners (GPs) coordinate services from other healthcare professionals. More involvement of the primary sector could potentially be valuable in detecting visual impairment.

Methods: Investigators apply the Medical Research Council framework for complex interventions to develop a primary care intervention with the GP as a key actor, aimed at identifying and coordinating care for patients with low vision. The development process will engage patients, relatives and relevant health professional stakeholders. The investigators will pilot test the feasibility of the intervention in a real-world general practice setting. The intervention model will be developed through a participatory approach using qualitative and creative methods such as graphical facilitation. The project aims to explore the potentials and limitations of general practice in relation to detection of preventable vision loss.

Ethics and dissemination: Ethics approval is obtained from local authority and the study meets the requirements from the Declaration of Helsinki. Dissemination is undertaken through research papers and to the broader public through podcasts and patient organisations.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Vision Impairment and Blindness Glaucoma Age-Related Macular Degeneration Cataract Diabetic Retinopathy

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SEQUENTIAL

Primary Study Purpose

SCREENING

Blinding Strategy

NONE

GP's or GP nurses, optometrists and the project ophtalmologist all give their anamnesis (and potential diagnosis). Their anamnesis are blinded to each other

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Three vision tests in general practice

All patients recruited in general practice are asked to fill out a patient questionnaire and examined:

\- Collenbrander Mixed contrast card: testing near vision binocularly at 40 cm, using both 100% and 10% contrast.

\- Amsler Test: Conducted for both eyes to check for central vision issues.

\- Visual Field Test: Performed using the Donders method to assess peripheral vision, conducted for both eyes.

After tests in general practice, all patients undergo a comprehensive vision assessment at local optician shops, which include the following tests:

* Habitual Vision Testing: Near and distance vision with habitual glasses.
* Best Corrected Distance Vision: Monocular and binocular.
* Intraocular Pressure Measurement Assessed using air tonometry or Icare.
* Ocular Imaging: 3D peripapillary and macula optical coherence tomography (OCT) scans, and fundus photography.

A project ophtalmologist analyze patient-data from optometrists.

Group Type OTHER

focus on vision impairment in older patients in general practice

Intervention Type OTHER

GP or GP nurse carry out the three vision tests. All patients visit optician shop collaborating with the project. An ophthalmologist review data from optometrists and provide an epicrisis to general practice. In case of acute conditions, the ophthalmologist is responsible for expedient treatment. If the patient needs further control by ophthalmologist within 12 month waiting time, general practice are responsible for referring the patient.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

focus on vision impairment in older patients in general practice

GP or GP nurse carry out the three vision tests. All patients visit optician shop collaborating with the project. An ophthalmologist review data from optometrists and provide an epicrisis to general practice. In case of acute conditions, the ophthalmologist is responsible for expedient treatment. If the patient needs further control by ophthalmologist within 12 month waiting time, general practice are responsible for referring the patient.

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* +70 years
* One or more chronic diseases
* Are followed by GP du to chronic disease

Exclusion Criteria

* Dementia diagnosis
* Known eye-diseases or are currently followed by private ophtalmologist
* Not able to understand Danish
Minimum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

University of Copenhagen

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Catharina Thiel Sandholdt

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Frans B Waldorff

Role: PRINCIPAL_INVESTIGATOR

Center for Almen Medicin, KU

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Søndre Lægehus (GP practice)

Køge, Køge, Denmark

Site Status RECRUITING

Louise Uhre General Practice

Køge, , Denmark

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

Denmark

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Catharina Thiel Sandholdt, phd

Role: CONTACT

+4531646460

Frans Boch Waldorff, prof

Role: CONTACT

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Mads Kristensen

Role: primary

+4560810552

Louise Uhre

Role: primary

+4556650042

References

Explore related publications, articles, or registry entries linked to this study.

Sandholdt CT, Jonsson ABR, Reventlow S, Bach-Holm D, Line K, Kolko M, Jacobsen MH, Mathiesen OH, Waldorff FB. DETECT: DEveloping and testing a model to identify preventive vision loss among older paTients in gEneral praCTice - protocol for a complex intervention in Denmark. BMJ Open. 2023 May 29;13(5):e069974. doi: 10.1136/bmjopen-2022-069974.

Reference Type BACKGROUND
PMID: 37247966 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

869353

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

869353

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.