Comparison of 18F-fluorodeoxyglucose Positron Emission Tomography and Coronary Computed Tomography in Assessing Vascular Inflammation

NCT ID: NCT01100671

Last Updated: 2018-03-14

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 120 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2010-04-30
• Study Completion Date: 2011-08-31

Brief Summary

Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.cardiac multidetector-row CT can provide measurements of coronary artery calcium (CAC), the degree of stenosis, and the characteristics of plaque including its potential vulnerability. Therefore, the purpose of the investigators study is to compare the usefulness of 18 FDG-PET and MDCT in assessing the vascular inflammatory status and vulnerability.

Conditions

Atherosclerosis

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Healthy patients

Cross section study

Intervention Type: OTHER

This is not intervention study. The purpose of the study is to examine the relationship of vascular inflammation assessed by 18FDG-PET and MDCT at the cross section setting

Interventions

Cross section study

This is not intervention study. The purpose of the study is to examine the relationship of vascular inflammation assessed by 18FDG-PET and MDCT at the cross section setting

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Healthy patients for visiting routine medical check in our clinic

Exclusion Criteria

• History of cardiovascular disease (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization)
• Diabetes
• Stage 2 hypertension (resting blood pressure, ≥ 160/100 mmHg)
• Malignancy
• Severe renal or hepatic disease
• Subjects taking medications that might affect inflammation such as NSIAD and statin

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Korea University

OTHER

Sponsor Role: lead

Responsible Party

Kyung Mook Choi

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Kyung Mook Choi, MD.PhD

Role: PRINCIPAL_INVESTIGATOR

Korea University

Locations

Hye Jin Yoo

Seoul, , South Korea

Countries

South Korea

References

Yoo HJ, Yong HS, Hwang SY, Eo JS, Hong HC, Seo JA, Kim SG, Kim NH, Choi DS, Baik SH, Choi KM. Association of pooled cohort risk scores with vascular inflammation and coronary artery calcification in Korean adults. Metabolism. 2016 Mar;65(3):1-7. doi: 10.1016/j.metabol.2015.10.016. Epub 2015 Oct 22.

Reference Type: DERIVED

PMID: 26892510 (View on PubMed)

Other Identifiers

PET_Coronary CT

Identifier Type: -

Identifier Source: org_study_id