Correlation Between Various Adipokines and Vascular Inflammation Measured by Positron Emission Tomography (PET) With 18F-fluoro-deoxyglucose (FDG) (18FDG-PET)

NCT ID: NCT01150006

Last Updated: 2010-06-29

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 90 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2010-04-30
• Study Completion Date: 2010-06-30

Brief Summary

The inflammatory state and composition of atherosclerotic plaques are considered the main contributing factors responsible for acute cardiovascular events, rather than the degree of stenosis. Recently, positron emission tomography (PET) with 18F-fluoro-deoxyglucose (FDG) has been suggested as a promising novel imaging technique to identify the inflammatory state of atherosclerotic plaque. Recently, a few clinical studies showed that circulating A-FABP level had a close relation with the development of atherosclerosis in human. Therefore, in the present study, the investigators examined the relationship between circulating A-FABP and vascular inflammation of carotid arteries measured using FDG-PET in healthy male subjects.

Conditions

Atherosclerosis

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Healthy male participants

Cross sectional study

Intervention Type: OTHER

This is not intervention study. The purpose of the study is to examine the relationship between various adipokine levels and PET imaging at the cross section setting

Interventions

Cross sectional study

This is not intervention study. The purpose of the study is to examine the relationship between various adipokine levels and PET imaging at the cross section setting

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Healthy male volunteers for visiting routine medical check in our clinic

Exclusion Criteria

• History of cardiovascular disease (myocardial infarction, unstable angina,stroke, or cardiovascular revascularization)
• Diabetes
• Hypertension
• Malignancy
• Severe renal or hepatic disease
• Subjects taking medications that might affect inflammation such as NSIAD and statin

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

Korea University

OTHER

Sponsor Role: lead

Responsible Party

Korea University

Principal Investigators

Kyung Mook Choi, MD.PhD

Role: PRINCIPAL_INVESTIGATOR

Korea University

Locations

Hye Jin Yoo

Seoul, , South Korea

Countries

South Korea

Other Identifiers

PET_Adipokines

Identifier Type: -

Identifier Source: org_study_id