Autoimmune Phenomena After Acute Stroke

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

28 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-12-31

Study Completion Date

2011-11-30

Brief Summary

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The damage of the brain parenchyma, as well as the stroke-induced dysfunction of the blood-brain-barrier can make previously hidden CNS antigens "visible", and can thus lead to the development of autoimmune mechanisms.

It seems plausible that stroke-associated immunodepression influences the development and the phenotype of these autoreactive immune responses.

This study will investigate whether cerebral ischemia leads to changes in the immune response, in particular to the development and/or proliferation of autoreactive effector T-cells and/or regulatory T-cells. Furthermore, the association between the severity and the phenotype of this autoimmune response and the clinical course, i.e. prognosis and mortality, will be investigated.

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Detailed Description

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Conditions

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Stroke

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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patients with acute media infarct

No interventions assigned to this group

controls with cardiovascular risks

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* acute media infarct or intracerebral bleeding within the last 36 h (patients)
* NIHSS \> 7 (patients)
* age \> 17 years (patients), age \> 54 years (controls)
* informed consent of patient or legal representative/ of control
* cardiovascular risk such as diabetes mellitus (control)