Lucrin® Depot Efficacy and Safety Monitoring Study in Patients With Advanced Prostate Cancer and Lower Urinary Tract Symptoms (LUTS)

NCT ID: NCT01078545

Last Updated: 2012-01-16

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

729 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-09-30

Study Completion Date

2010-11-30

Brief Summary

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The purpose of the study is to determine the influence of GnRH (gonadotropin releasing hormone) analogue - Lucrin Depot 11.25 mg (Lucrin Depot 3.75mg - in Ukraine) administration on intensity of lower urinary tract symptoms (LUTS) in patients with diagnosed locally advanced and/or metastatic prostate cancer and LUTS.

Detailed Description

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The remaining target is:

\- to assess the intensity of LUTS in Polish and Ukrainian patients with locally advanced and metastatic prostate cancer, previously untreated with hormonal therapy

Conditions

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Advanced Prostate Cancer Lower Urinary Tract Symptoms

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Adv. PCa patients with LUTS treated with GnRH analogue

Patients with advanced prostate cancer and lower urinary tract symptoms treated with GnRH analogue Lucrin Depot 11.25 mg (Lucrin Depot 3.75mg - in Ukraine)

Leuprolide acetate Depot Susp. 11.25 mg (Poland), 3.75 mg (Ukraine)

Intervention Type DRUG

Leuprolide acetate 11.25 mg every 3 months sc or im, number of injections during the trial - 5 in Poland, Leuprolide acetate 3.75 mg every 1 month sc or im, number of injections during the trial - 12 in Ukraine.

Interventions

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Leuprolide acetate Depot Susp. 11.25 mg (Poland), 3.75 mg (Ukraine)

Leuprolide acetate 11.25 mg every 3 months sc or im, number of injections during the trial - 5 in Poland, Leuprolide acetate 3.75 mg every 1 month sc or im, number of injections during the trial - 12 in Ukraine.

Intervention Type DRUG

Other Intervention Names

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Lupron Depot/Leuprolide acetate 11.25 mg Lucrin Depot 11.25 mg Lupron Depot/Leuprolide acetate 3.75 mg Lucrin Depot 3.75 mg

Eligibility Criteria

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Inclusion Criteria

* Age \> 50 years
* Locally advanced (T3-T4) and/or metastatic (N+/M+) hormone-sensitive prostate cancer, confirmed by histological examination
* Presence of lower urinary tract symptoms (LUTS)-IPSS \>0
* Treatment with Lucrin® Depot is the routine therapy in the patient. The decision as to Lucrin® Depot choice will not be associated with patient's participation in the study, but will result from the best medical knowledge and practice.
* Until inclusion into PMOS the patient has not been treated with GnRH analogue.
* The patient, before inclusion into the study, has not been treated by surgery (radical prostatectomy).

Exclusion Criteria

* Patients will not be included into the study if any contraindications to treatment with Lucrin® Depot exist, or if there are other treatment options which, according to the present medical knowledge, are potentially more beneficial for the patient.
* Physician or patient can stop treatment at any moment, if any indications or reasons exist.
Minimum Eligible Age

50 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Fraktal.com.pl

UNKNOWN

Sponsor Role collaborator

Med-net.pl

UNKNOWN

Sponsor Role collaborator

Abbott

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jozef Haczynski, MD, PhD

Role: STUDY_DIRECTOR

Abbott Laboratories, Poland

Locations

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Site Reference ID/Investigator# 31076

Bełchatów, , Poland

Site Status

Site Reference ID/Investigator# 31002

Bialystok, , Poland

Site Status

Site Reference ID/Investigator# 30977

Bialystok, , Poland

Site Status

Site Reference ID/Investigator# 31030

Bialystok, , Poland

Site Status

Site Reference ID/Investigator# 31048

Bialystok, , Poland

Site Status

Site Reference ID/Investigator# 31083

Bobrowniki, , Poland

Site Status

Site Reference ID/Investigator# 31028

Bydgoszcz, , Poland

Site Status

Site Reference ID/Investigator# 31014

Bytom, , Poland

Site Status

Site Reference ID/Investigator# 31006

Bytom, , Poland

Site Status

Site Reference ID/Investigator# 31018

Bytom, , Poland

Site Status

Site Reference ID/Investigator# 31007

Ciechanów, , Poland

Site Status

Site Reference ID/Investigator# 31004

Elblag, , Poland

Site Status

Site Reference ID/Investigator# 31090

Elblag, , Poland

Site Status

Site Reference ID/Investigator# 31044

Ełk, , Poland

Site Status

Site Reference ID/Investigator# 30994

Florentynów, , Poland

Site Status

Site Reference ID/Investigator# 9803

Gdansk, , Poland

Site Status

Site Reference ID/Investigator# 31057

Gdansk, , Poland

Site Status

Site Reference ID/Investigator# 31101

Gdansk, , Poland

Site Status

Site Reference ID/Investigator# 31097

Gdansk, , Poland

Site Status

Site Reference ID/Investigator# 30984

Gliwice, , Poland

Site Status

Site Reference ID/Investigator# 30976

Gmina Brwinów, , Poland

Site Status

Site Reference ID/Investigator# 31009

Gmina Poddębice, , Poland

Site Status

Site Reference ID/Investigator# 31051

Imielnik Stary, , Poland

Site Status

Site Reference ID/Investigator# 31023

Inowrocław, , Poland

Site Status

Site Reference ID/Investigator# 31074

Inowrocław, , Poland

Site Status

Site Reference ID/Investigator# 31032

Jankowo, , Poland

Site Status

Site Reference ID/Investigator# 31067

Jarosławiec, , Poland

Site Status

Site Reference ID/Investigator# 30995

Jastków, , Poland

Site Status

Site Reference ID/Investigator# 31065

Jastrzębie Zdrój, , Poland

Site Status

Site Reference ID/Investigator# 31031

Jastrzębie Zdrój, , Poland

Site Status

Site Reference ID/Investigator# 31054

Jelenia Góra, , Poland

Site Status

Site Reference ID/Investigator# 30997

Katowice, , Poland

Site Status

Site Reference ID/Investigator# 31036

Katowice, , Poland

Site Status

Site Reference ID/Investigator# 31055

Kielce, , Poland

Site Status

Site Reference ID/Investigator# 30999

Kielce, , Poland

Site Status

Site Reference ID/Investigator# 31102

Kluczbork, , Poland

Site Status

Site Reference ID/Investigator# 31068

Kolbudy, , Poland

Site Status

Site Reference ID/Investigator# 31020

Konin, , Poland

Site Status

Site Reference ID/Investigator# 31019

Krakow, , Poland

Site Status

Site Reference ID/Investigator# 31087

Krakow, , Poland

Site Status

Site Reference ID/Investigator# 31050

Krakow, , Poland

Site Status

Site Reference ID/Investigator# 31025

Krakow, , Poland

Site Status

Site Reference ID/Investigator# 31043

Krakow, , Poland

Site Status

Site Reference ID/Investigator# 31011

Krakow, , Poland

Site Status

Site Reference ID/Investigator# 31061

Krakow, , Poland

Site Status

Site Reference ID/Investigator# 31053

Krakow, , Poland

Site Status

Site Reference ID/Investigator# 31029

Kurów, , Poland

Site Status

Site Reference ID/Investigator# 31012

Legnica, , Poland

Site Status

Site Reference ID/Investigator# 31040

Leszno, , Poland

Site Status

Site Reference ID/Investigator# 31082

Lidzbark Warmiński, , Poland

Site Status

Site Reference ID/Investigator# 31086

Lodz, , Poland

Site Status

Site Reference ID/Investigator# 31052

Lodz, , Poland

Site Status

Site Reference ID/Investigator# 31047

Lodz, , Poland

Site Status

Site Reference ID/Investigator# 31089

Lodz, , Poland

Site Status

Site Reference ID/Investigator# 31060

Lodz, , Poland

Site Status

Site Reference ID/Investigator# 31049

Lublin, , Poland

Site Status

Site Reference ID/Investigator# 31100

Lublin, , Poland

Site Status

Site Reference ID/Investigator# 33278

Lublin, , Poland

Site Status

Site Reference ID/Investigator# 31103

Lublin, , Poland

Site Status

Site Reference ID/Investigator# 31104

Lublin, , Poland

Site Status

Site Reference ID/Investigator# 30998

Lublin, , Poland

Site Status

Site Reference ID/Investigator# 31056

Michałowice, , Poland

Site Status

Site Reference ID/Investigator# 31001

Milcz, , Poland

Site Status

Site Reference ID/Investigator# 31085

Nysa, , Poland

Site Status

Site Reference ID/Investigator# 30993

Oborniki Śląskie, , Poland

Site Status

Site Reference ID/Investigator# 30974

Olsztyn, , Poland

Site Status

Site Reference ID/Investigator# 31080

Olsztyn, , Poland

Site Status

Site Reference ID/Investigator# 30989

Opole, , Poland

Site Status

Site Reference ID/Investigator# 30978

Opole, , Poland

Site Status

Site Reference ID/Investigator# 30982

Opole, , Poland

Site Status

Site Reference ID/Investigator# 31033

Opole, , Poland

Site Status

Site Reference ID/Investigator# 31075

Opole, , Poland

Site Status

Site Reference ID/Investigator# 31042

Ostrów Wielkopolski, , Poland

Site Status

Site Reference ID/Investigator# 31000

Piotrkow Trybunalski, , Poland

Site Status

Site Reference ID/Investigator# 31069

Piła, , Poland

Site Status

Site Reference ID/Investigator# 31045

Poznan, , Poland

Site Status

Site Reference ID/Investigator# 31088

Poznan, , Poland

Site Status

Site Reference ID/Investigator# 31021

Poznan, , Poland

Site Status

Site Reference ID/Investigator# 31058

Poznan, , Poland

Site Status

Site Reference ID/Investigator# 31034

Poznan, , Poland

Site Status

Site Reference ID/Investigator# 30985

Poznan, , Poland

Site Status

Site Reference ID/Investigator# 30979

Puszczykowo, , Poland

Site Status

Site Reference ID/Investigator# 31005

Puławy, , Poland

Site Status

Site Reference ID/Investigator# 31064

Puławy, , Poland

Site Status

Site Reference ID/Investigator# 31022

Pyskowice, , Poland

Site Status

Site Reference ID/Investigator# 31013

Płock, , Poland

Site Status

Site Reference ID/Investigator# 31016

Radlin, , Poland

Site Status

Site Reference ID/Investigator# 31099

Radom, , Poland

Site Status

Site Reference ID/Investigator# 31041

Rzeszów, , Poland

Site Status

Site Reference ID/Investigator# 31024

Siedlce, , Poland

Site Status

Site Reference ID/Investigator# 30988

Siemianowice Śląskie, , Poland

Site Status

Site Reference ID/Investigator# 31063

Sieradz, , Poland

Site Status

Site Reference ID/Investigator# 31015

Sosnowiec, , Poland

Site Status

Site Reference ID/Investigator# 30983

Starachowice, , Poland

Site Status

Site Reference ID/Investigator# 31084

Suwałki, , Poland

Site Status

Site Reference ID/Investigator# 31092

Suwałki, , Poland

Site Status

Site Reference ID/Investigator# 33277

Suwałki, , Poland

Site Status

Site Reference ID/Investigator# 31008

Swarzędz, , Poland

Site Status

Site Reference ID/Investigator# 30975

Szczecin, , Poland

Site Status

Site Reference ID/Investigator# 31046

Szczecin, , Poland

Site Status

Site Reference ID/Investigator# 30992

Szczecin, , Poland

Site Status

Site Reference ID/Investigator# 31035

Szczecin, , Poland

Site Status

Site Reference ID/Investigator# 31003

Świętochłowice, , Poland

Site Status

Site Reference ID/Investigator# 31079

Tarnowskie Góry, , Poland

Site Status

Site Reference ID/Investigator# 31071

Tarnów, , Poland

Site Status

Site Reference ID/Investigator# 31091

Tarnów, , Poland

Site Status

Site Reference ID/Investigator# 30980

Tomaszów Mazowiecki, , Poland

Site Status

Site Reference ID/Investigator# 31059

Torun, , Poland

Site Status

Site Reference ID/Investigator# 30987

Turek, , Poland

Site Status

Site Reference ID/Investigator# 31066

Warsaw, , Poland

Site Status

Site Reference ID/Investigator# 31037

Warsaw, , Poland

Site Status

Site Reference ID/Investigator# 31105

Warsaw, , Poland

Site Status

Site Reference ID/Investigator# 31106

Warsaw, , Poland

Site Status

Site Reference ID/Investigator# 31093

Warsaw, , Poland

Site Status

Site Reference ID/Investigator# 31094

Warsaw, , Poland

Site Status

Site Reference ID/Investigator# 31095

Warsaw, , Poland

Site Status

Site Reference ID/Investigator# 31081

Warsaw, , Poland

Site Status

Site Reference ID/Investigator# 31078

Warsaw, , Poland

Site Status

Site Reference ID/Investigator# 30986

Wieliczka, , Poland

Site Status

Site Reference ID/Investigator# 31027

Wroclaw, , Poland

Site Status

Site Reference ID/Investigator# 31038

Wroclaw, , Poland

Site Status

Site Reference ID/Investigator# 31062

Wroclaw, , Poland

Site Status

Site Reference ID/Investigator# 31070

Wroclaw, , Poland

Site Status

Site Reference ID/Investigator# 31077

Wroclaw, , Poland

Site Status

Site Reference ID/Investigator# 31072

Wroclaw, , Poland

Site Status

Site Reference ID/Investigator# 31098

Zabrze, , Poland

Site Status

Site Reference ID/Investigator# 30996

Zamość, , Poland

Site Status

Site Reference ID/Investigator# 31073

Złotniki, , Poland

Site Status

Site Reference ID/Investigator# 30981

Żory, , Poland

Site Status

Site Reference ID/Investigator# 31010

Łask, , Poland

Site Status

Site Reference ID/Investigator# 31096

Łazy, , Poland

Site Status

Site Reference ID/Investigator# 31039

Łomża, , Poland

Site Status

Site Reference ID/Investigator# 31108

Dnipro, , Ukraine

Site Status

Site Reference ID/Investigator# 31109

Dnipro, , Ukraine

Site Status

Site Reference ID/Investigator# 31111

Donetsk, , Ukraine

Site Status

Site Reference ID/Investigator# 31112

Kharkiv, , Ukraine

Site Status

Site Reference ID/Investigator# 31113

Kharkiv, , Ukraine

Site Status

Site Reference ID/Investigator# 31114

Kharkiv, , Ukraine

Site Status

Site Reference ID/Investigator# 31209

Kiev, , Ukraine

Site Status

Site Reference ID/Investigator# 31110

Kiev, , Ukraine

Site Status

Site Reference ID/Investigator# 21103

Kiev, , Ukraine

Site Status

Site Reference ID/Investigator# 31107

Kiev, , Ukraine

Site Status

Site Reference ID/Investigator# 31115

Simferopol, , Ukraine

Site Status

Countries

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Poland Ukraine

Other Identifiers

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P10-612

Identifier Type: -

Identifier Source: org_study_id

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