Long Term Study of Solifenacin Succinate and Tamsulosin Hydrochloride Oral Controlled Absorption System (OCAS) in Males With Lower Urinary Tract Symptoms

NCT ID: NCT01021332

Last Updated: 2024-12-03

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

1067 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-04-26

Study Completion Date

2011-12-14

Brief Summary

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Clinical study to examine the safety, tolerability and efficacy of long-term combination therapy of tamsulosin and solifenacin in the treatment of males with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) with a substantial storage component.

Detailed Description

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This is an open-label extension study following the double blind 905-CL-055 study

Conditions

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Lower Urinary Tract Symptoms Benign Prostatic Hyperplasia

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Total Group

Participants who received at least one dose of open-label fixed dose combination (FDC) treatment

Group Type EXPERIMENTAL

tamsulosin hydrochloride/solifenacin succinate fixed dose combination (0.4 mg/6 mg)

Intervention Type DRUG

oral

tamsulosin hydrochloride/solifenacin succinate fixed dose combination (0.4 mg/9 mg)

Intervention Type DRUG

oral

Interventions

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tamsulosin hydrochloride/solifenacin succinate fixed dose combination (0.4 mg/6 mg)

oral

Intervention Type DRUG

tamsulosin hydrochloride/solifenacin succinate fixed dose combination (0.4 mg/9 mg)

oral

Intervention Type DRUG

Other Intervention Names

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EC905 Vesomni EC905

Eligibility Criteria

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Inclusion Criteria

* Completion of 12 weeks double-blind treatment in Study 905-CL-055

Exclusion Criteria

* Any significant PVR volume (\>150 mL)
Minimum Eligible Age

45 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Astellas Pharma Europe B.V.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Use Central Contact

Role: STUDY_CHAIR

Astellas Pharma Global Development

Locations

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Innsbruck, , Austria

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Vienna, , Austria

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Minsk, , Belarus

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Minsk, , Belarus

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Minsk, , Belarus

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Antwerp, , Belgium

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Edegem, , Belgium

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Ghent, , Belgium

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Leuven, , Belgium

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Liège, , Belgium

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Hradec Králové, , Czechia

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Ostrava, , Czechia

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Pilsen, , Czechia

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Roudnice nad Labem, , Czechia

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Uherské Hradiště, , Czechia

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Ústí nad Labem, , Czechia

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Zd'ar Nad Sazavou, , Czechia

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Colmar, , France

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Montluçon, , France

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Orléans, , France

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Paris, , France

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Paris, , France

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Pierre-Bénite, , France

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Bautzen, , Germany

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Eisleben Lutherstadt, , Germany

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Frankfurt, , Germany

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Ganderkesee, , Germany

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Hagenow, , Germany

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Halle, , Germany

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Hamburg, , Germany

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Henningsdorf, , Germany

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Hettstedt, , Germany

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Koblenz, , Germany

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Leipzig, , Germany

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Leipzig, , Germany

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Neustadt in Sachsen, , Germany

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Radebeul, , Germany

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Sachsen, , Germany

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Trier, , Germany

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Uetersen, , Germany

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Avellino, , Italy

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Catanzaro, , Italy

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Palermo, , Italy

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Treviglio, , Italy

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Amsterdam, , Netherlands

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Apeldoorn, , Netherlands

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Doetinchem, , Netherlands

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Maastricht, , Netherlands

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Sneek, , Netherlands

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Tilburg, , Netherlands

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Winterswijk, , Netherlands

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Bielsko-Biala, , Poland

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Bydgoszcz, , Poland

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Krakow, , Poland

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Puławy, , Poland

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Warsaw, , Poland

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Więcbork, , Poland

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Nitra, , Slovakia

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Piešťany, , Slovakia

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Prešov, , Slovakia

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Skalica, , Slovakia

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Trenčín, , Slovakia

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Cardiff, , United Kingdom

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Chorley, , United Kingdom

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Liverpool, , United Kingdom

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Northwood, , United Kingdom

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Oxford, , United Kingdom

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Reading, , United Kingdom

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Sheffield, , United Kingdom

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Taunton, , United Kingdom

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Countries

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Austria Belarus Belgium Czechia France Germany Italy Netherlands Poland Slovakia United Kingdom

Related Links

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https://www.astellasclinicalstudyresults.com/study.aspx?ID=39

Link to results on Astellas Clinical Study Results website

Other Identifiers

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2008-001212-20

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

905-CL-057

Identifier Type: -

Identifier Source: org_study_id