A Humanitarian Device Exemption Treatment Protocol of TheraSphere For Treatment of Unresectable Hepatocellular Carcinoma

NCT ID: NCT01076517

Last Updated: 2021-04-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

APPROVED_FOR_MARKETING

Study Classification

EXPANDED_ACCESS

Brief Summary

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To provide Therasphere treatment for patients diagnosed with unresectable liver cancer.

Detailed Description

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Conditions

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Liver Cancer

Interventions

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Therasphere

Beta-emitting 90yttrium encapsulated in glass microspheres for intraarterial administration to the liver.

Intervention Type DEVICE

Other Intervention Names

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HCC hepatocellular carcinoma treatment

Eligibility Criteria

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Inclusion Criteria

Patients of any age, of any race or sex, who have hepatocellular carcinoma of the liver, and who are able to give informed consent, will be eligible. Patients must have an ECOG Performance Status score of \</= 2, with a life expectancy of \>/= 3 months, non-pregnant with an acceptable contraception in premenopausal women. Patients must be \>4 weeks since prior radiation or prior surgery and at least 1 month post other chemotherapy.

Exclusion Criteria

* Contraindications to angiography and selective visceral catheterization
* Evidence of potential delivery of greater than 16.5 mCi (30 Gy absorbed dose) of radiation to the lungs
* Evidence of any detectable Tc-99m MAA flow to the stomach or duodenum, after application of established angiographic techniques to stop or mitigate such flow (ex. placing catheter distal to gastric vessels)
* Significant extrahepatic disease representing an imminent life-threatening outcome
* Severe liver dysfunction or pulmonary insufficiency
* Active uncontrolled infection
* Significant underlying medical or psychiatric illness
* Pregnancy

Patients will be excluded: if they have a co-morbid disease or an acute or chronic condition that would preclude safe delivery of TheraSphere treatment and place the patient at undue risk.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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BTG International Inc.

OTHER

Sponsor Role collaborator

Stanford University

OTHER

Sponsor Role lead

Responsible Party

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Daniel Yung-Ho Sze

Professor of Radiology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Daniel Yung-Ho Sze

Role: PRINCIPAL_INVESTIGATOR

Stanford University

Locations

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Stanford University School of Medicine

Stanford, California, United States

Site Status

Countries

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United States

Other Identifiers

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HEP0016

Identifier Type: OTHER

Identifier Source: secondary_id

IRB-14324 (NOT RESEARCH)

Identifier Type: -

Identifier Source: org_study_id

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