Therasphere® for Treatment of Unresectable Primary Liver Cancer and Metastatic Liver Cancer

NCT ID: NCT00701168

Last Updated: 2017-08-23

Basic Information

• Recruitment Status: NO_LONGER_AVAILABLE
• Study Classification: EXPANDED_ACCESS

Brief Summary

The purpose of this protocol is to provide supervised and limited access to Therasphere® treatment for patients with primary liver cancer and chemotherapy refractory liver metastasis who cannot be treated by surgical removal of the affected part of the liver. Patient response to treatment and any side effects of Therasphere® treatment will be examined.

Conditions

Carcinoma, Hepatocellular; Neoplasm Metastasis

Interventions

yttrium Y 90 microspheres (Therasphere®)

This is a local therapy for unresectable liver tumors with limited treatment options. It may be repeated under special circumstances.

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• Confirmed diagnosis of primary or metastatic intrahepatic carcinoma
• The cancer must be unresectable with limited established treatment options
• ECOG Performance Status Score 0-2
• Age 19 years or older
• Able to comprehend and provide written informed consent

Exclusion Criteria

• Any pre-treatment laboratory findings within 15 days of treatment demonstrating:
• Absolute granulocyte count ≤ 1,500/ul
• Platelet count ≤ 75,000/ul
• Serum creatinine > 2.0 mg/dl
• Serum bilirubin ≥ 2.0 mg/dl
• Any of the following contraindications to angiography and selective visceral catheterization:
• History of severe allergy or intolerance to any contrast media, narcotics, sedatives, or atropine
• Bleeding, diathesis, not correctable by usual forms of therapy
• Severe peripheral vascular disease that would preclude catheterization
• Substantial venous shunt away from the liver
• Evidence of potential delivery of greater than 11 mCi (20 Gy absorbed dose) of radiation to the lungs on either 1) first Therasphere® administration; or 2) cumulative delivery of radiation to the lungs over multiple treatments
• Evidence of any detectable Tc-99 MAA flow to the stomach or duodenum, application of established angiographic techniques to stop such flow
• Significant extrahepatic disease representing an imminent life- threatening situation outcome
• Severe liver dysfunction or pulmonary insufficiency
• Active uncontrolled infection
• Significant underlying medical or psychiatric illness
• Pregnant women may not participate

• Minimum Eligible Age: 19 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Leo W. Jenkins Cancer Center

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Suzanne Russo, MD

Role: PRINCIPAL_INVESTIGATOR

East Carolina University School of Medicine

Locations

Leo W Jenkins Cancer Center at East Carolina University School of Medicine

Greenville, North Carolina, United States

Countries

United States

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Other Identifiers

LJCC 07-04

Identifier Type: -

Identifier Source: org_study_id