Cross-over Study to Evaluate the Effect on Trough Forced Expiratory Volume in One Second (FEV1) After 4 Weeks Treatment With CHF 5188 pMDI qd in Adult Patients With Persistent Asthma

NCT ID: NCT01070524

Last Updated: 2017-03-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

113 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-01-31

Study Completion Date

2010-07-31

Brief Summary

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Cross-over study to evaluate the effect on trough FEV1 after 4 weeks treatment with CHF5188 pMDI qd in adult patients with persistent asthma

Detailed Description

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A randomised, double-blind, multinational, multicentre, active-controlled, 3-way cross-over study to evaluate the effect on trough FEV1 after 4 weeks treatment with CHF5188 pMDI qd in adult patients with moderate or severe persistent asthma

Conditions

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Asthma

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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CHF 5188 pMDI

Group Type EXPERIMENTAL

CHF 5188 pMDI

Intervention Type DRUG

CHF 5188: fixed combination budesonide/carmoterol

Budesonide extrafine pMDI

Group Type ACTIVE_COMPARATOR

Budesonide extrafine pMDI

Intervention Type DRUG

Budesonide extrafine pMDI

Seretide(r) Evohaler(r)

Group Type ACTIVE_COMPARATOR

Seretide(r) Evohaler(r)

Intervention Type DRUG

Seretide(r) Evohaler(r): fixed combination fluticasone/salmeterol

Interventions

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CHF 5188 pMDI

CHF 5188: fixed combination budesonide/carmoterol

Intervention Type DRUG

Budesonide extrafine pMDI

Budesonide extrafine pMDI

Intervention Type DRUG

Seretide(r) Evohaler(r)

Seretide(r) Evohaler(r): fixed combination fluticasone/salmeterol

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Moderate or severe asthma partly controlled with ICS or ICS/LABA
* FEV1 ≥ 60% and ≤ 90% of predicted for the patient normal value

Exclusion Criteria

* Diagnosis of COPD
* History or current evidence of significant cardiovascular disease
* Uncontrolled concomitant disease
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Chiesi Farmaceutici S.p.A.

INDUSTRY

Sponsor Role lead

Responsible Party

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The Medicines Evaluation Unit Ltd

Principal Investigators

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Dave Singh, MD

Role: PRINCIPAL_INVESTIGATOR

The Medicines Evaluation Unit Ltd

Locations

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The Medicines Evaluation Unit Ltd, The Langley Building, Southmoor Road

Manchester, , United Kingdom

Site Status

Countries

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United Kingdom

Related Links

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https://www.clinicaltrialsregister.eu/ctr-search/search?query=2009-013759-32

Study Record on EU Clinical Trials Register including results

Other Identifiers

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2009-013759-32

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

CCD-0909-PR-0020

Identifier Type: -

Identifier Source: org_study_id

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