High-Field MRI Characterization of Wrist and Hand Cartilage Abnormalities in Inflammatory and Chronic Rheumatisms

NCT ID: NCT01058161

Last Updated: 2014-08-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

34 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-12-31

Study Completion Date

2013-02-28

Brief Summary

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The present project aims at evaluating the diagnostic potential of high-field MRI (3 Teslas) for joint disease. At this field, given that isotropic image resolution of 400 microns can be obtained, one could expect an early detection of joint abnormalities. The additional aim of this project will be to develop a quantitative analyse of the corresponding high-resolution images.

Detailed Description

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Conditions

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Abnormality Inflammation Rheumatism

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Suspects or affected by rheumatoid polyarthritis

Group Type OTHER

high-field MRI (3 Teslas)

Intervention Type OTHER

high-field MRI (3 Teslas)

stiffening spondylitis with axial and peripheral infringement

Group Type OTHER

high-field MRI (3 Teslas)

Intervention Type OTHER

high-field MRI (3 Teslas)

high-field MRI (3 Teslas)

Intervention Type OTHER

high-field MRI (3 Teslas)

polyarthralgies with or without arthritis

Affected by connectivity with anti-nuclear antibody positive and / or specific antibodies, suffering of polyarthralgias with or without arthritis

Group Type OTHER

high-field MRI (3 Teslas)

Intervention Type OTHER

high-field MRI (3 Teslas)

high-field MRI (3 Teslas)

Intervention Type OTHER

high-field MRI (3 Teslas)

Healthy control

Group Type OTHER

high-field MRI (3 Teslas)

Intervention Type OTHER

high-field MRI (3 Teslas)

high-field MRI (3 Teslas)

Intervention Type OTHER

high-field MRI (3 Teslas)

not inflammatory control

Presenting a degenerative osteoarthritis of the wrist traumatic comment, noticed radiologically, which will serve as not inflammatory control.

Group Type OTHER

high-field MRI (3 Teslas)

Intervention Type OTHER

high-field MRI (3 Teslas)

high-field MRI (3 Teslas)

Intervention Type OTHER

high-field MRI (3 Teslas)

Interventions

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high-field MRI (3 Teslas)

high-field MRI (3 Teslas)

Intervention Type OTHER

high-field MRI (3 Teslas)

high-field MRI (3 Teslas)

Intervention Type OTHER

high-field MRI (3 Teslas)

high-field MRI (3 Teslas)

Intervention Type OTHER

high-field MRI (3 Teslas)

high-field MRI (3 Teslas)

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* gp Suspects or affected by rheumatoid polyarthritis

1. Morning articular Stiffness of at least 15 minutes.
2. Arthalgias or Arthritises of at least three joints(articulations), among which those of the hand.
3. Possible rheumatoid Presence of a factor(mailman) and\\or Antibody anti peptides positive citrullinés.
4. Typical possible radiological Hurts on the standard clichés(pictures) of the reached(affected) joints(articulations).
* gp Affected by stiffening spondylitis with axial and peripheral infringement :

. Lumbago and steepness lumbar vertebra inflammatory. 2. Arthralgias and\\or peripheral arthritises 3. Possible presence of an allèle HLA 4. Possible presence of a sacro-illite 5. Absence of the other rheumatic markers
* gp Affected by connectivity with anti-nuclear antibody positive and / or specific antibodies, suffering of polyarthralgias with or without arthritis
* gp Healthy control
* gp Presenting a degenerative osteoarthritis of the wrist traumatic comment, noticed radiologically, which will serve as not inflammatory control.

Exclusion Criteria

* Claustrophobia,
* metallic foreign bodies,
* pacemakers The pregnant women,
* parturients or who breast-feed are excluded from the study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Assistance Publique Hopitaux De Marseille

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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sandrine guis, PU PH

Role: PRINCIPAL_INVESTIGATOR

Assistance Publique Hopitaux De Marseille

Locations

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Assistance Publique Hopitaux de Marseille

Marseille, , France

Site Status

Countries

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France

Other Identifiers

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2009 28

Identifier Type: OTHER

Identifier Source: secondary_id

2009-A01040-57

Identifier Type: -

Identifier Source: org_study_id

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