Dosing Study of Cranberry Capsules for the Prevention of Bacteriuria in Nursing Home Residents
NCT ID: NCT01033383
Last Updated: 2013-08-15
Study Results
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View full resultsBasic Information
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COMPLETED
PHASE1
80 participants
INTERVENTIONAL
2009-12-31
2010-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
SINGLE_GROUP
PREVENTION
QUADRUPLE
Study Groups
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3 placebo capsules
3 placebo capsules qd
Placebo
36 milligram (mg) placebo capsule taken before quiet hours of sleep (qhs).
1 cranberry capsule & 2 placebo capsules
1 active cranberry capsule and 2 placebo capsules qd
Placebo
36 milligram (mg) placebo capsule taken before quiet hours of sleep (qhs).
Cranberry Capsule
36 milligram (mg) cranberry capsule, taken before quiet hours of sleep (qhs).
2 cranberry capsules & 1 placebo capsule
2 active cranberry capsules and 1 placebo capsules qd
Placebo
36 milligram (mg) placebo capsule taken before quiet hours of sleep (qhs).
Cranberry Capsule
36 milligram (mg) cranberry capsule, taken before quiet hours of sleep (qhs).
3 cranberry capsules
3 active cranberry capsules qd
Cranberry Capsule
36 milligram (mg) cranberry capsule, taken before quiet hours of sleep (qhs).
Interventions
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Placebo
36 milligram (mg) placebo capsule taken before quiet hours of sleep (qhs).
Cranberry Capsule
36 milligram (mg) cranberry capsule, taken before quiet hours of sleep (qhs).
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* residents who are on chronic suppressive antibiotic or anti-infective (i.e., mandelamine) therapy for recurrent UTI;
* residents with end stage renal disease on dialysis (they do not regularly produce urine);
* residents unable to produce a baseline clean catch urine specimen for collection;
* residents on warfarin therapy because of a potential interaction of warfarin and cranberry juice;
* residents with a history of nephrolithiasis because cranberry may increase the risk of nephrolithiasis.
65 Years
FEMALE
Yes
Sponsors
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National Institute on Aging (NIA)
NIH
National Center for Research Resources (NCRR)
NIH
Yale University
OTHER
Responsible Party
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Principal Investigators
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Manisha Juthani-Mehta, MD
Role: PRINCIPAL_INVESTIGATOR
Yale University
Locations
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Northbridge Health Care Center
Bridgeport, Connecticut, United States
Sheriden Woods Health Care Center
Bristol, Connecticut, United States
The Carolton Chronic and Convalescent Hospital
Fairfield, Connecticut, United States
Glastonbury Health Care Center
Glastonbury, Connecticut, United States
Middlesex Health Care Center
Middletown, Connecticut, United States
Wadsworth Glen Health Care and Rehabilitation Center
Middletown, Connecticut, United States
Beacon Brook Health Care Center
Naugatuck, Connecticut, United States
Laurel Ridge Health Care Center
Ridgefield, Connecticut, United States
Shady Knoll Health Center
Seymour, Connecticut, United States
Litchfield Woods Health Care Center
Torrington, Connecticut, United States
Maefair Health Care Center
Trumbull, Connecticut, United States
Masonicare Health Center
Wallingford, Connecticut, United States
Abbott Terracee Health Center
Waterbury, Connecticut, United States
Saint Mary Home
West Hartford, Connecticut, United States
Countries
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References
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Bianco L, Perrelli E, Towle V, Van Ness PH, Juthani-Mehta M. Pilot randomized controlled dosing study of cranberry capsules for reduction of bacteriuria plus pyuria in female nursing home residents. J Am Geriatr Soc. 2012 Jun;60(6):1180-1. doi: 10.1111/j.1532-5415.2012.03976.x. No abstract available.
Williams G, Stothart CI, Hahn D, Stephens JH, Craig JC, Hodson EM. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev. 2023 Nov 10;11(11):CD001321. doi: 10.1002/14651858.CD001321.pub7.
Williams G, Hahn D, Stephens JH, Craig JC, Hodson EM. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev. 2023 Apr 17;4(4):CD001321. doi: 10.1002/14651858.CD001321.pub6.
Other Identifiers
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