Randomized Comparison of Warfarin Dosing Quality Between the Hamilton Nomogram and a Commercial Computer System
NCT ID: NCT01024452
Last Updated: 2011-07-20
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE3
1298 participants
INTERVENTIONAL
2009-11-30
2010-08-31
Brief Summary
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Hypothesis: Mean TTR of patients managed with the commercial computer system is non-inferior to management with the validated Hamilton Nomogram.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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DAWN AC
DAWN AC
computerized dosing management system for anticoagulation clinics
Hamilton Nomogram
Hamilton Nomogram
simple nomogram for warfarin maintenance dosing
Interventions
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DAWN AC
computerized dosing management system for anticoagulation clinics
Hamilton Nomogram
simple nomogram for warfarin maintenance dosing
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* INR target range 2-3
* At least 3 historical INRs on maintenance therapy
* At least 1 historical INR in the last 3 months
Exclusion Criteria
* On multiple pill strengths
18 Years
ALL
No
Sponsors
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Population Health Research Institute
OTHER
Responsible Party
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Population Health Research Institute
Principal Investigators
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Stuart Connolly, MD
Role: PRINCIPAL_INVESTIGATOR
Director, Division of Cardiology
Locations
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Hamilton General Hospital
Hamilton, Ontario, Canada
Countries
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References
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Poller L, Keown M, Ibrahim S, Lowe G, Moia M, Turpie AG, Roberts C, van den Besselaar AM, van der Meer FJ, Tripodi A, Palareti G, Shiach C, Bryan S, Samama M, Burgess-Wilson M, Heagerty A, Maccallum P, Wright D, Jespersen J; European Action on Anticoagulation (EAA). A multicentre randomised assessment of the DAWN AC computer-assisted oral anticoagulant dosage program. Thromb Haemost. 2009 Mar;101(3):487-94.
Kim YK, Nieuwlaat R, Connolly SJ, Schulman S, Meijer K, Raju N, Kaatz S, Eikelboom JW. Effect of a simple two-step warfarin dosing algorithm on anticoagulant control as measured by time in therapeutic range: a pilot study. J Thromb Haemost. 2010 Jan;8(1):101-6. doi: 10.1111/j.1538-7836.2009.03652.x. Epub 2009 Oct 14.
Other Identifiers
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09-283
Identifier Type: -
Identifier Source: org_study_id
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