Clinical Phenotyping Resource and Biobank Core of the Michigan O'Brien Renal Center
NCT ID: NCT01016613
Last Updated: 2024-10-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
1800 participants
OBSERVATIONAL
2009-01-31
2030-07-31
Brief Summary
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This O'Brien Kidney Research Core will create opportunities for novel insights through characterization of tissue profiles that will define new disease markers and molecular pathways and will be available to all kidney investigators on the www. It will thereby fundamentally alter the starting point for research into prevention of progression of these kidney diseases. C-PROBE is an essential element of the center grant and presents a biomedical resource core consisting of: (1) clinical phenotyping (that is, systematic identification of observable physical and biomedical characteristics) of kidney disease patients including the accurate measurement of kidney function; and (2) a specimen BioBank which will store blood, urine and kidney tissue samples. A key component of C-PROBE is therefore that it contains a proven mechanism to collect samples from high risk groups including minorities, at the institutions of University of Michigan Health System, St. John Hospital, Wayne State University in Michigan, John H. Stroger Hospital in Illinois, Temple University Health System in Pennsylvania, and Levine Children's Hospital in North Carolina. This mechanism will feed the other Cores and provide biomedical investigators with approved projects the access to a dynamic pool of well characterized high risk kidney disease patients and their biological specimens to conduct high caliber translational research.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Chronic Kidney Disease Cohort
chronic kidney disease patients with any type of kidney disease
No interventions assigned to this group
Matched Control Group
Healthy controls
No interventions assigned to this group
Trios
First degree relatives of pediatric chronic kidney disease cohort members
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* a small number of people without chronic kidney disease
Exclusion Criteria
* people who have had a kidney transplant
* people unable or unwilling to provide consent
* women who are pregnant or nursing
* adults who have polycystic kidney disease
* institutionalized persons
* people currently participating in a blinded interventional clinical trial
ALL
Yes
Sponsors
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St. John Health System, Michigan
OTHER
Temple University
OTHER
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
University of Michigan
OTHER
Responsible Party
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Markus Bitzer
Professor of Medicine
Principal Investigators
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Subramanium Pennathur, MBBS
Role: PRINCIPAL_INVESTIGATOR
University of Michigan
Crystal A Gadegbeku, MD
Role: STUDY_DIRECTOR
The Cleveland Clinic
Matthias Kretzler, MD
Role: STUDY_DIRECTOR
University of Michigan
Markus Bitzer, MD
Role: STUDY_DIRECTOR
University of Michigan
Locations
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University of Michigan Health System
Ann Arbor, Michigan, United States
Wayne State University
Detroit, Michigan, United States
St. John's Health System
Detroit, Michigan, United States
Levine Children's Hospital
Charlotte, North Carolina, United States
Temple University
Philadelphia, Pennsylvania, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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