Effect of Turmeric on Diabetic Nephropathy

NCT ID: NCT01015937

Last Updated: 2009-11-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-03-31

Study Completion Date

2009-08-31

Brief Summary

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The purpose of this study is to investigate whether turmeric is effective in improvement of diabetic nephropathy and in decrease in the amount of proteinuria and cytokine levels.

Detailed Description

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Diabetic nephropathy is leading cause of ESRF that many therapy recommended for it. In this study, we investigate effect of turmeric on diabetic nephropathy, thus we selected diabetic nephropathy patients and divided them into 2 groups. One group received turmeric + ACE inhibitor + Angiotensin II receptor blocker (ARB) and the second group received only ACE inhibitor + ARB.

Conditions

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Diabetic Nephropathy Proteinuria

Keywords

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diabetes nephropathy turmeric serum IL8 serum TGFb serumINF urinary IL8 urine TGFb

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Turmeric

diabetic nephropathy patient

more than 300 mg/proteinuria

Group Type ACTIVE_COMPARATOR

Turmeric extract

Intervention Type DRUG

turmeric 500 mg TID for 45 days

ACE inhibitor + ATI blocker

diabetic nephropathy

more than 300 mg/day proteinuria

Group Type ACTIVE_COMPARATOR

Turmeric extract

Intervention Type DRUG

turmeric 500 mg TID for 45 days

Angiotensin-converting enzyme (ACE) inhibitor + Angiotensin-II type 1 receptor (ATI) blocker

Intervention Type DRUG

maximum dosage as patient tolerated for 45 days

Interventions

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Turmeric extract

turmeric 500 mg TID for 45 days

Intervention Type DRUG

Angiotensin-converting enzyme (ACE) inhibitor + Angiotensin-II type 1 receptor (ATI) blocker

maximum dosage as patient tolerated for 45 days

Intervention Type DRUG

Other Intervention Names

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turmeric enalapril losartan

Eligibility Criteria

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Inclusion Criteria

* diabetic nephropathy
* more than 300 mg proteinuria/day
* age more than 18 years old

Exclusion Criteria

* DM type 1
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Shiraz University of Medical Sciences

OTHER

Sponsor Role collaborator

Shaheed Faghihi Hospital

OTHER

Sponsor Role lead

Responsible Party

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Shiraz University of Medical Science

Principal Investigators

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maryam pakfetrat, assistant professor

Role: PRINCIPAL_INVESTIGATOR

Shiraz nephro-urology research center

Locations

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Clinic

Shiraz, Fars, Iran

Site Status

Countries

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Iran

Other Identifiers

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3997

Identifier Type: -

Identifier Source: org_study_id